ArticleNature communications2019
Plant circadian rhythms regulate the effectiveness of a glyphosate-based herbicide.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- A Meta-Analysis of Biostimulant Yield Effectiveness in Field Trials.Frontiers in plant science · 2022Pooled it
- Polar Lattice-Distorted Motifs Enable Synergy of Local Polarization/Dipole Fields for Concurrent Glyphosate Wastewater Remediation and CO Evolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanistic insights into adventitious root formation in Cinnamomum kanehirae stem cuttings based on phenotypic, physiological, and transcriptomic analyses.BMC plant biology · 2026Article
- Review
- Glyphosate Adsorption on Metal-Organic Framework MACS omega · 2025Article
- Using plant circadian programs to optimize agrochemical use.The New phytologist · 2025Review
- UV RESISTANCE LOCUS 8 signalling enhances photosynthetic resilience to herbicide-induced damage in Arabidopsis thaliana.The New phytologist · 2025Article
- Diurnal Rhythmicity in the Rhizosphere Microbiome-Mechanistic Insights and Significance for Rhizosphere Function.Plant, cell & environment · 2025Review
- Circadian gating: concepts, processes, and opportunities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- BioClocks UK: driving robust cycles of discovery to impact.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike.Journal of biological rhythms · 2024Review
- Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach.Annals of general psychiatry · 2024Article
- Glyphosate Separating and Sensing for Precision Agriculture and Environmental Protection in the Era of Smart Materials.Environmental science & technology · 2023Review
- Localized Surface Plasmon Resonance-Based Nanosensor for Rapid Detection of Glyphosate in Food Samples.Biosensors · 2023Article
- Multi-omics analyses reveal the crosstalk between the circadian clock and the response to herbicide application inFrontiers in plant science · 2023Article
- Effects of glyphosate exposure on the miRNA expression profile and construction of the miRNA-mRNA regulatory network in mouse bone marrow cells.Functional & integrative genomics · 2022Article
- The circadian clock ticks in plant stress responses.Stress biology · 2022Review
- Article
- Role of Circadian Rhythms in Major Plant Metabolic and Signaling Pathways.Frontiers in plant science · 2022Review
- Chemical Perturbation of Chloroplast-Related Processes Affects Circadian Rhythms of Gene Expression inFrontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Herbicides increase crop yields by allowing weed control and harvest management. Glyphosate is the most widely-used herbicide active ingredient, with $11 billion spent annually on glyphosate-containing products applied to >350 million hectares worldwide, using about 8.6 billion kg of glyphosate. The herbicidal effectiveness of glyphosate can depend upon the time of day of spraying. Here, we show that the plant circadian clock regulates the effectiveness of glyphosate. We identify a daily and circadian rhythm in the inhibition of plant development by glyphosate, due to interaction between glyphosate activity, the circadian oscillator and potentially auxin signalling. We identify that the circadian clock controls the timing and extent of glyphosate-induced plant cell death. Furthermore, the clock controls a rhythm in the minimum effective dose of glyphosate. We propose the concept of agricultural chronotherapy, similar in principle to chronotherapy in medical practice. Our findings provide a platform to refine agrochemical use and development, conferring future economic and environmental benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.