Evidence map›Paper›PMID 31420544›Full record

ArticleNature communications2019

Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab.

Carla Serra-Peinado, Judith Grau-Expósito, Laura Luque-Ballesteros, Antonio Astorga-Gamaza, Jordi Navarro, Jenny Gallego-Rodriguez, Mario Martin, Adrià Curran, Joaquin Burgos, Esteban Ribera and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Lymph-Node-Based CD3Journal of virology · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. CD20Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. The Contributions of Clinical Pharmacology to HIV Cure Research.Clinical pharmacology and therapeutics · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 1 country.

Carla Serra-PeinadoInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1413-3990
Judith Grau-ExpósitoInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9350-2429
Laura Luque-BallesterosInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9515-5889
Antonio Astorga-GamazaInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Jordi NavarroInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7187-0367
Jenny Gallego-RodriguezInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Mario MartinInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-6435-0374
Adrià CurranInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1263-0814
Joaquin BurgosInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-8445-3047
Esteban RiberaInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3752-8808
Berta RaventósInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-4668-2970
Rein WillekensInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-7791-3682
Ariadna TorrellaInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0003-1848-5096
Bibiana PlanasInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1490-7127
Rosa BadíaInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-8222-5697
Felipe GarciaInfectious Disease Department, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-7658-5832
Josep CastellvíDepartment of Pathology, Hospital Vall d'Hebrón, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-5745-9996
Meritxell GenescàInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
Vicenç FalcóInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9626-0023
Maria J BuzonInfectious Disease Department, Hospital Universitari Vall d'Hebrón, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain. mariajose.buzon@vhir.org.ORCID http://orcid.org/0000-0003-4427-9413
Universitat Autònoma de Barcelona · ESHospital Clínic de Barcelona · ES

Funding

Characterization of in vivo resting CD4 T cells expressing HIV RNA in ART-treated individualsR21AI118411 · NIAID · FDN INSTITUTE/RESEARCH/VALL D'HEBRON HOS · PI BUZON, MARIA J · 2015 to 2016
$297k
NIAID NIH HHS R21 AI118411
6 · The paper itself

Abstract

The identification of exclusive markers to target HIV-reservoir cells will represent a significant advance in the search for therapies to cure HIV. Here, we identify the B lymphocyte antigen CD20 as a marker for HIV-infected cells in vitro and in vivo. The CD20 molecule is dimly expressed in a subpopulation of CD4-positive (CD4

Indexed as

Virus ActivationVirus LatencyAntigens, CD20Anti-HIV AgentsCD4-Positive T-LymphocytesFlow CytometryHIV-1HIV InfectionsHumansImmunologic FactorsImmunologic MemoryLeukocytes, MononuclearLymph NodesLymphocyte ActivationRituximabRNA, ViralAntigens, CD20Anti-HIV AgentsImmunologic FactorsRituximabRNA, Viral

Identifiers

PMID31420544
PMCPMC6697690
OpenAlexW2968786654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.