Evidence map›Paper›PMID 31420528›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice.

Daxesh P Patel, Tingting Yan, Donghwan Kim, Henrique B Dias, Kristopher W Krausz, Shioko Kimura, Frank J Gonzalez

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  5. Review
  6. Exploring the safety parameters ofToxicological research · 2025
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  10. Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  11. Review
  12. Withaferin A in the Treatment of Liver Diseases: Progress and Pharmacokinetic Insights.Drug metabolism and disposition: the biological fate of chemicals · 2022
    Review
  13. Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Article
  14. Article
  15. Review
  16. Review
  17. Nutrients · 2020
    Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Daxesh P PatelLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.).
Tingting YanLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.).
Donghwan KimLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.).
Henrique B DiasLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.).
Kristopher W KrauszLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.).
Shioko KimuraLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.).
Frank J GonzalezLaboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (D.P.P., T.Y., D.K., H.B.D., K.W.K., S.K., F.J.G.) and Laboratory of Cellular Biophysics and Inflammation, Pontifical Catholic University of Rio Grande do Sul, Rio Grande do Sul, Brazil (H.B.D.) gonzalef@mail.nih.gov.
Center for Cancer Research · USNational Cancer Institute · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic steatohepatitis (NASH) is the progressive stage of nonalcoholic fatty liver disease that highly increases the risk of cirrhosis and liver cancer, and there are few therapeutic options available in the clinic. Withaferin A (WA), extracted from the ayurvedic medicine

Indexed as

AnimalsDiet, High-FatDose-Response Relationship, DrugLiverMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseRandom AllocationWithanolideswithaferin AWithanolides

Identifiers

PMID31420528
PMCPMC6800446
OpenAlexW2969120993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.