ArticleProceedings of the National Academy of Sciences of the United States of America2019
Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Stepwise allelic trajectory of ETP2 underlies trade-off between UVB tolerance and submergence adaptation in Arabidopsis thaliana.Nature communications · 2026Article
- Seasonal Drought Timing Shapes Flowering Phenology Directly and Through Biotic Interactions.Ecology letters · 2026Article
- EasyOmics: A graphical interface for population-scale omics data association, integration, and visualization.Plant communications · 2025Article
- Historic rewiring of grass flowering time pathways and implications for crop improvement under climate change.The New phytologist · 2025Review
- Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae.Nature ecology & evolution · 2024Article
- Flowering time: From physiology, through genetics to mechanism.Plant physiology · 2024Review
- Plasticity and environment-specific relationships between gene expression and fitness inbioRxiv : the preprint server for biology · 2024Article
- A large-effect fitness trade-off across environments is explained by a single mutation affecting cold acclimation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- UV RESISTANCE LOCUS 8-Mediated UV-B Response Is Required Alongside CRYPTOCHROME 1 for Plant Survival in Sunlight under Field Conditions.Plant & cell physiology · 2024Article
- The role of gene presence-absence variations on genetic incompatibility in Asian rice.The New phytologist · 2023Article
- Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns.PLoS biology · 2023Article
- Transposable elements maintain genome-wide heterozygosity in inbred populations.Nature communications · 2022Article
- A Pleiotropic Flowering Time QTL Exhibits Gene-by-Environment Interaction for Fitness in a Perennial Grass.Molecular biology and evolution · 2022Article
- In Silico Pleiotropy Analysis in KEGG Signaling Networks Using a Boolean Network Model.Biomolecules · 2022Article
- MicroRNA miR394 regulates flowering time in Arabidopsis thaliana.Plant cell reports · 2022Article
- High-throughput measurement of plant fitness traits with an object detection method using Faster R-CNN.The New phytologist · 2022Article
- Genetic architecture and adaptation of flowering time among environments.The New phytologist · 2021Article
- A single-nucleotide change underlies the genetic assimilation of a plastic trait.Science advances · 2021Article
- Whose trait is it anyways? Coevolution of joint phenotypes and genetic architecture in mutualisms.Proceedings. Biological sciences · 2021Article
- Natural selection on traits and trait plasticity in Arabidopsis thaliana varies across competitive environments.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contrary to previous assumptions that most mutations are deleterious, there is increasing evidence for persistence of large-effect mutations in natural populations. A possible explanation for these observations is that mutant phenotypes and fitness may depend upon the specific environmental conditions to which a mutant is exposed. Here, we tested this hypothesis by growing large-effect flowering time mutants of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.