Evidence map›Paper›PMID 31420499›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

High Availability of the α7-Nicotinic Acetylcholine Receptor in Brains of Individuals with Mild Cognitive Impairment: A Pilot Study Using

Jennifer M Coughlin, Leah H Rubin, Yong Du, Steven P Rowe, Jeffrey L Crawford, Hailey B Rosenthal, Sarah M Frey, Erica S Marshall, Laura K Shinehouse, Allen Chen and 13 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Assessment of [Biomolecules · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Evaluation of [Receptors (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. EJNMMI research · 2024
    Article
  14. Article
  15. Review
  16. PET molecular imaging for pathophysiological visualization in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2023
    Review
  17. Development ofACS chemical neuroscience · 2022
    Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jennifer M CoughlinDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland jcoughl2@jhmi.edu.
Leah H RubinDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Yong DuDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Steven P RoweDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Jeffrey L CrawfordDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Hailey B RosenthalDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Sarah M FreyDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Erica S MarshallDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Laura K ShinehouseDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Allen ChenDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Caroline L SpeckDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Yuchuan WangDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Wojciech G LesniakDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Il MinnDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Arnold BakkerDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Vidyulata KamathDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Gwenn S SmithDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Marilyn S AlbertDepartment of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Babak Behnam AzadDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Robert F DannalsDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Andrew HortiDepartment of Radiology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Dean F WongDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Martin G PomperDepartment of Psychiatry, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
NIA NIH HHS P30 AG066507NIA NIH HHS P50 AG005146
6 · The paper itself

Abstract

Emerging evidence supports a hypothesized role for the α7-nicotinic acetylcholine receptor (α7-nAChR) in the pathophysiology of Alzheimer's disease.

Indexed as

Azabicyclo CompoundsCyclic S-OxidesPositron-Emission TomographyAgedAged, 80 and overalpha7 Nicotinic Acetylcholine ReceptorBrainCognitive DysfunctionCross-Sectional StudiesFemaleHumansMalePilot Projects3-(1,4-diazabicyclo(3.2.2)nonan-4-yl)-6-fluorodibenzo(b,d)thiophene 5,5-dioxidealpha7 Nicotinic Acetylcholine ReceptorAzabicyclo CompoundsCyclic S-Oxides18F-ASEMcholinergicdementianAChRPET

Identifiers

PMID31420499
PMCPMC9374031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.