Evidence map›Paper›PMID 31420455›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Neuronal Myocyte-Specific Enhancer Factor 2D (MEF2D) Is Required for Normal Circadian and Sleep Behavior in Mice.

Jennifer A Mohawk, Kimberly H Cox, Makito Sato, Seung-Hee Yoo, Masashi Yanagisawa, Eric N Olson, Joseph S Takahashi

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  3. Current Evidence for Sleep States inCurrent sleep medicine reports · 2026
    Review
  4. Local adaptation ofEcology and evolution · 2024
    Article
  5. Article
  6. Tob Regulates the Timing of Sleep Onset at Night inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. The Molecular and Biological Function of MEF2D in Leukemia.Advances in experimental medicine and biology · 2024
    Review
  8. Orthologs ofSleep advances : a journal of the Sleep Research Society · 2024
    Article
  9. SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. A conserved role forSleep advances : a journal of the Sleep Research Society · 2023
    Article
  12. Recent advances in sleep genetics.Current opinion in neurobiology · 2021
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jennifer A MohawkDepartment of Neuroscience, Peter O'Donnell Jr. Brain Insitute.
Kimberly H CoxDepartment of Neuroscience, Peter O'Donnell Jr. Brain Insitute.ORCID 0000-0002-7097-9563
Makito SatoHoward Hughes Medical Institute.
Seung-Hee YooDepartment of Neuroscience, Peter O'Donnell Jr. Brain Insitute.
Masashi YanagisawaHoward Hughes Medical Institute.ORCID 0000-0002-7358-4022
Eric N OlsonDepartment of Molecular Biology, Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9111.
Joseph S TakahashiDepartment of Neuroscience, Peter O'Donnell Jr. Brain Insitute, Joseph.Takahashi@UTSouthwestern.edu.ORCID 0000-0003-0384-8878
Allen Institute for Brain Science · USHoward Hughes Medical Institute · USThe University of Texas Southwestern Medical Center · US

Funding

Deciphering the role of a novel micropeptide in cardiac function and dysfunctionR01HL130253 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2016 to 2023
$4.4M
Molecular Dissection of Myoblast Fusion In Muscle Development and RegenerationR01AR067294 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2015 to 2019
$1.8M
Identifying circadian rhythm genes from mouse mutantsR01MH078024 · NIMH · NORTHWESTERN UNIVERSITY · PI TAKAHASHI, JOSEPH S · 2007 to 2011
$1.8M
Transcriptional Architecture and Chromatin Landscape of Circadian Clocks in AgingR01AG045795 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI GREEN, CARLA B., TAKAHASHI, JOSEPH S · 2013 to 2017
$1.5M
NHLBI NIH HHS R01 HL130253NIAMS NIH HHS R01 AR067294NIA NIH HHS R01 AG045795NIMH NIH HHS R01 MH078024
6 · The paper itself

Abstract

The transcription factor, myocyte enhancer factor-2 (MEF2), is required for normal circadian behavior in

Indexed as

AnimalsBehavior, AnimalCircadian RhythmCLOCK ProteinsLightMaleMEF2 Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutMotor ActivityRNASleepSleep Wake DisordersSuprachiasmatic NucleusCLOCK ProteinsMef2d protein, mouseMEF2 Transcription FactorsRNAcircadianMEF2Dsleep

Identifiers

PMID31420455
PMCPMC6774416
OpenAlexW2967031024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.