ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019
Neuropsychological latent classes at enrollment and postmortem neuropathology.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Late-Life Vascular Risk Score in Association With Postmortem Cerebrovascular Disease Brain Pathologies.Stroke · 2021Trial
- Alzheimer disease-related biomarkers and cancer-related cognitive decline: the Thinking and Living with Cancer study.Journal of the National Cancer Institute · 2024Article
- Diagnosing Mild Cognitive Impairment Among Racially Diverse Older Adults: Comparison of Consensus, Actuarial, and Statistical Methods.Journal of Alzheimer's disease : JAD · 2022Article
- Using Mixture Modeling to Construct Subgroups of Cognitive Aging in the Wisconsin Longitudinal Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- Latent Cognitive Class at Enrollment Predicts Future Cognitive Trajectories of Decline in a Community Sample of Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women.Journal of Alzheimer's disease : JAD · 2021Article
- A Latent Transition Analysis Model to Assess Change in Cognitive States over Three Occasions: Results from the Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2020Article
- Predicting Amyloid-β Levels in Amnestic Mild Cognitive Impairment Using Machine Learning Techniques.Journal of Alzheimer's disease : JAD · 2020Article
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7 authors.
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Abstract
introductionWe classified individuals based on their baseline performance on cognitive measures and investigated the association between cognitive classifications and neuropathological findings ∼7 years later, as an external validator.
methodsBrain autopsies of 779 decedents were examined. Baseline latent class analysis on 10 neuropsychological measures was previously assigned: mixed-domains impairment (n = 39, 5%), memory-specific impairment (n = 210, 27%), frontal impairment (n = 113, 14.5%), average cognition (n = 360, 46.2%), and superior cognition (n = 57, 7.3%). Linear regressions and risks ratios were used to examine the relation of latent class assignment at enrollment with neuropathological indices.
resultsAmyloid β, tau, and transactive response DNA-binding protein 43 were associated with mixed-domains impairment and memory-specific impairment classes ∼7 years before death. Moderate arteriolosclerosis was associated with membership in the frontal impairment class. DISCUSSION: Our findings support the use of latent class models that incorporate more comprehensive neuropsychological measures to classify cognitive impairment.
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