Evidence map›Paper›PMID 31420060›Full record

ArticleItalian journal of pediatrics2019

Donkey's Milk in the Management of Children with Cow's Milk protein allergy: nutritional and hygienic aspects.

Lucrezia Sarti, Mina Martini, Giovanni Brajon, Simona Barni, Federica Salari, Iolanda Altomonte, Giuseppe Ragona, Francesca Mori, Neri Pucci, Giada Muscas and 3 more

Open access · goldAbstract read
In one paragraph

Article in Italian journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 65 citations in OpenAlex.

  1. Oral food challenges in FPIES: A narrative review and proposals for emergency and home-based management of acute FPIES reaction.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Lucrezia SartiAllergy Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy. lucrezia.sarti@gmail.com.
Mina MartiniDepartment of Veterinary Science, University of Pisa, Pisa, Italy.
Giovanni BrajonIstituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri, Florence, Italy.
Simona BarniAllergy Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Federica SalariDepartment of Veterinary Science, University of Pisa, Pisa, Italy.
Iolanda AltomonteDepartment of Veterinary Science, University of Pisa, Pisa, Italy. altomonte@vet.unipi.it.
Giuseppe RagonaIstituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri, Florence, Italy.
Francesca MoriAllergy Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Neri PucciAllergy Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Giada MuscasNutrition Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Fina BelliNutrition Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Franco CorriasIstituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri, Florence, Italy.
Elio NovembreAllergy Unit, department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
Meyer Children's Hospital · ITIstituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana · ITUniversity of Pisa · IT

Funding

Regione Toscana open call for research projects in the Nutraceuticals sector (D.D. 650/2014)
6 · The paper itself

Abstract

backgroundThe therapeutic strategy for children with cow's milk allergy (CMA) consists in the elimination of cow's milk (CM) from their diet. Donkey's milk (DM) has been reported to be an adequate alternative, mainly to his nutritional similarities with human milk (HM) and excellent palatability. The aim of present prospective study was to evaluate the nutritional impact of DM on the diet of children with CMA in term of children growth.

methodsBefore the nutritional trial on children and during the study the health and hygiene risks and nutritional and nutraceuticals parameters of DM were monitored. Children with CMA were identified by the execution of in vivo and in vitro tests for CM and subsequent assessment of tolerability of DM with oral food challenge (OFC). Finally, we prescribed DM to a selected group of patients for a period of 6 months during which we monitored the growth of children. A total of 81 children, 70 with IgE mediated cow's milk protein allergy (IgE-CMPA) and 11 with Food Protein Induced Enterocolitis Syndrome to CM (CM-FPIES), were enrolled.

resultsSeventy-eight out of 81 patients underwent the OFC with DM and only one patient with IgE-CMPA (1.5 %) reacted. Twenty-two out of 81 patients took part of the nutritional trial. All the 22 patients took and tolerated the DM, moreover DM did not change the normal growth rate of infants.

conclusionsIn conclusion, DM resulted safe in term of health and hygiene risks and nutritionally adequate: no negative impact on the normal growth rate of children was assessed. Therefore, it may be a suitable alternative for the management of IgE mediated CMA and FPIES, also in the first 6 months of life, if adequately supplemented.

Indexed as

EquidaeAdolescentAnimalsCattleChildChild, PreschoolFemaleHumansInfantItalyMaleMilkMilk HypersensitivityProspective StudiesQuality of LifeSkin TestsChildrencow’s milk allergydonkey milkHygienic riskNutraceuticalNutritional

Identifiers

PMID31420060
PMCPMC6698021
OpenAlexW2968763307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.