Evidence map›Paper›PMID 31420057›Full record

ArticleTrials2019

Effects of oral Nigella sativa oil on the expression levels and serum concentrations of adiponectin, PPAR-γ, and TNF-α in overweight and obese women: a study protocol for a crossover-designed, double-blind, placebo-controlled randomized clinical trial.

Elham Razmpoosh, Sara Safi, Mahta Mazaheri, Amin Salehi-Abargouei, Nooshin Abdollahi, Majid Nazari, Hossein Fallahzadeh, Azadeh Nadjarzadeh

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Effect ofCurrent medicinal chemistry · 2025
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  4. Pooled it
  5. Trial
  6. Article
  7. Ethical Considerations and Equipoise in Cancer Surgery.Indian journal of surgical oncology · 2024
    Review
  8. Review
  9. The effect ofJournal of diabetes and metabolic disorders · 2022
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  10. IsVascular health and risk management · 2022
    Review
  11. Article
  12. Article
  13. Effects ofFrontiers in pharmacology · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Elham RazmpooshDepartment of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Sara SafiDepartment of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahta MazaheriFaculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Amin Salehi-AbargoueiDepartment of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nooshin AbdollahiDepartment of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Majid NazariDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein FallahzadehDepartment of Biostatistics and Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Azadeh NadjarzadehDepartment of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. azadehnajarzadeh@gmail.com.
Shahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

Iran National Science Foundation 96012986Shahid Sadoughi University of Medical Sciences 961020
6 · The paper itself

Abstract

backgroundObesity is a major public health problem in recent decades. The accumulation of excessive fat promotes inflammatory status. Meanwhile, herbal products are marketed for their weight-loss properties, such as Nigella sativa (N. Sativa) which has been used for centuries to treat rheumatoid arthritis, diabetes, and asthma; recently, the anti-obesity characteristics of N. sativa have also been indicated. However, the exact mechanisms and cellular-related pathways are still unclear. Thus, we will aim to assess the effects of oral N. sativa on the gene expression of inflammatory and adipogenesis-related factors, including TNF-α, PPAR-γ, and adiponectin as well as assessing their serum concentrations among obese and overweight individuals.

methodsObese and overweight women aged 25-55 years with a body mass index (BMI) of 25-35 kg/m DISCUSSION: The present study will investigate the probable cellular pathways for the anti-obesity effects of N. sativa in overweight/obese women.

trial registrationIranian Registry of Clinical Trials, IRCT20180528039884N1 . Registered on 2nd of July, 2018.

Indexed as

Randomized Controlled Trials as TopicAdiponectinAdultCarumCross-Over StudiesDouble-Blind MethodFemaleHumansMiddle AgedObesityOverweightPlant OilsPPAR gammaTumor Necrosis Factor-alphaAdiponectinADIPOQ protein, humancaraway oilPlant OilsPPAR gammaTumor Necrosis Factor-alphaAdiponectinNigella sativaObesityOverweightPeroxisome proliferator-activated receptorsTumor necrosis factor-alpha

Identifiers

PMID31420057
PMCPMC6698025
OpenAlexW2967769845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.