Observational studyCritical care (London, England)2019
Capillary refill time variation induced by passive leg raising predicts capillary refill time response to volume expansion.
Observational study in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Capillary Refill Time Variation Induced by Passive Leg Raising Predict Capillary Refill Time Variation After a Fluid Load in Patients With Circulatory Failure.
Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock
Clinical Predictors of Capillary Refill Time and Their Association With Triage Categories From the Emergency Department Perspective: A Cross-Sectional Study
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis.Critical care (London, England) · 2023Pooled it
- Fluid challenge in critically ill patients receiving haemodynamic monitoring: a systematic review and comparison of two decades.Critical care (London, England) · 2022Pooled it
- Understanding the Nuanced Concept of Hemodynamic Incoherence and Its Underlying Physiology.Journal of clinical medicine · 2026Review
- Acute hemodynamic tests to determine the status of macro-to-microcirculatory coupling during septic shock resuscitation.Critical care (London, England) · 2026Article
- Passive leg raising, peripheral perfusion, and cardiac output: insights into hemodynamic coherence.Critical care (London, England) · 2026Article
- Perfusion index and fluid responsiveness: Are we asking the right question?Journal of intensive medicine · 2026Article
- Passive leg raising and microvascular skin blood flow to predict peripheral tissue perfusion fluid responsiveness.Critical care (London, England) · 2026Observational
- Capillary refill time as a bedside perfusion indicator: associations with vital signs and triage acuity in the emergency department: a cross-sectional study.BMC emergency medicine · 2025Observational
- DiCARTJournal of clinical monitoring and computing · 2025Article
- The intricate relationship between capillary refill time and systemic hemodynamics in septic shock.Annals of intensive care · 2025Review
- Gingival capillary refill time: a new approach to assess tissue perfusion.Critical care (London, England) · 2025Article
- Point of View: A Holistic Four-Interface Conceptual Model for Personalizing Shock Resuscitation.Journal of personalized medicine · 2025Review
- Sepsis Resuscitation: Time to Embrace a Restrictive Fluid Strategy?Journal of the American College of Emergency Physicians open · 2025Article
- Research Progress on the Measurement Methods and Clinical Significance of Capillary Refill Time.Sensors (Basel, Switzerland) · 2024Review
- Early peripheral perfusion monitoring in septic shock.European journal of medical research · 2024Review
- Capillary Refill Time as a Part of Routine Physical Examination in Critically Ill Patients Undergoing Vasoactive Therapy: A Prospective Study.Journal of clinical medicine · 2024Article
- Skin mottling score assesses peripheral tissue hypoperfusion in critically ill patients following cardiac surgery.BMC anesthesiology · 2024Article
- Monitoring capillary refill time in septic shock.Intensive care medicine · 2024Article
- Capillary refill time response to a fluid challenge or a vasopressor test: an observational, proof-of-concept study.Annals of intensive care · 2024Article
- Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of personalized medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA peripheral perfusion-targeted resuscitation during early septic shock has shown encouraging results. Capillary refill time, which has a prognostic value, was used. Adding accuracy and predictability on capillary refill time (CRT) measurement, if feasible, would benefit to peripheral perfusion-targeted resuscitation. We assessed whether a reduction of capillary refill time during passive leg raising (ΔCRT-PLR) predicted volume-induced peripheral perfusion improvement defined as a significant decrease of capillary refill time following volume expansion.
methodsThirty-four patients with acute circulatory failure were selected. Haemodynamic variables, metabolic variables (PCO
resultsThe least significant change in the capillary refill time was 25% [95% CI, 18-30]. We defined CRT responders as patients showing a reduction of at least 25% of capillary refill time after volume expansion. A decrease of 27% in ΔCRT-PLR predicted peripheral perfusion improvement with a sensitivity of 87% [95% CI, 73-100] and a specificity of 100% [95% CI, 74-100]. The ROC
conclusionΔCRT-PLR predicted peripheral perfusion response following volume expansion. This simple low-cost and non-invasive diagnostic method could be used in peripheral perfusion-targeted resuscitation protocols.
trial registrationCPP Lyon Sud-Est II ANSM: 2014-A01034-43 Clinicaltrial.gov, NCT02248025 , registered 13th of September 2014.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.