Evidence map›Paper›PMID 31420036›Full record

ArticleBMC psychiatry2019

Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction.

Xiaowei Tang, Chao Zhou, Ju Gao, Weiwei Duan, Miao Yu, Wenhuan Xiao, Xiaobin Zhang, Hui Dong, Xiang Wang, Xiangrong Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  17. Dysregulation of Synaptic Plasticity Markers in Schizophrenia.Indian journal of clinical biochemistry : IJCB · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Xiaowei TangDepartment of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
Chao ZhouDepartment of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
Ju GaoShanghai Changning Mental Health Center, Shanghai, 210029, China.
Weiwei DuanJining Medical University, Jining, 272067, Shandong, China.
Miao YuDepartment of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China.
Wenhuan XiaoAffiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, Jiangsu, China.
Xiaobin ZhangAffiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, Jiangsu, China.
Hui DongAffiliated WuTaiShan Hospital of Medical College of Yangzhou University, Yangzhou, 225003, Jiangsu, China.
Xiang WangMedical Psychological Institute of the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
Xiangrong ZhangDepartment of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu Province, 210029, People's Republic of China. drxrz@hotmail.com.
Yangzhou University · CNNanjing Brain Hospital · CNNanjing Medical University · CNJining Medical University · CNSecond Xiangya Hospital of Central South University · CNShanghai Changning Mental Health Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo measure the serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in deficit schizophrenia (DS), in order to examine the association between these two neurotrophic factors (NFs) and cognitive performance.

methodsA total of 109 male patients [51 DS and 58 non-deficit schizophrenia (NDS)] with schizophrenia and 40 sex and age matched healthy controls (HC) participated in this study. Processing speed, attention, executive function, and working memory of all subjects were assessed by means of a battery of classical neuropsychological tests. Serum BDNF and GDNF levels were measured simultaneously using a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA).

resultsThere were significant differences in the overall cognitive test scores between three groups (all p < 0.001). Serum BDNF levels were significantly lower in patients (DS and NDS) than in HC (p < 0.001). Furthermore, BDNF levels were lower in the DS compared to the NDS group, although not significantly. However, there was no difference in the GDNF levels between patients (DS and NDS) and HC. GDNF levels were positively correlated with scores of Stroop words only (r = 0.311, p = 0.033), Stroop colors only (r = 0.356, p = 0.014) and Stroop interference (r = 0.348, p = 0.016) in DS group.

conclusionSerum BDNF may be an unsuitable biomarker for DS, despite a significant decrease in schizophrenia patients. The different neurocognitive performance between the DS and NDS patients indicates that DS may be a separate clinical entity of schizophrenia. Finally, higher serum GDNF levels are associated with better cognitive performance in DS patients, indicating a possible neuroprotective function in DS.

Indexed as

Schizophrenic PsychologyAdultBiomarkersBrain-Derived Neurotrophic FactorChinaCognitive DysfunctionGlial Cell Line-Derived Neurotrophic FactorHumansMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSchizophreniaYoung AdultBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorGDNF protein, humanGlial Cell Line-Derived Neurotrophic FactorBrain-derived neurotrophic factorDeficit schizophreniaGlial cell line-derived neurotrophic factorNeurocognitionSchizophrenia

Identifiers

PMID31420036
PMCPMC6697959
OpenAlexW2969130803

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.