ArticleBMC gastroenterology2019
Current diagnosis and management of Crohn's disease in China: results from a multicenter prospective disease registry.
Article in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Utility of endoscopic ileocecal valve-plasty for Crohn's disease: a propensity-matched retrospective study.Surgical endoscopy · 2026Article
- Disease burden of inflammatory bowel disease and subtypes in older adults in 172 high- and middle-income countries: Trends from 2000 to 2023 and projections to 2040.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- Long-Term Effectiveness and Persistence of Ustekinumab in Crohn's Disease Patients: An Observational Retrospective Study.Journal of clinical medicine · 2026Article
- Escalation to biologics after corticosteroids in patients with newly diagnosed Crohn's disease in Japan: a claims analysis from 2010 to 2021.Intestinal research · 2026Article
- Cost-effectiveness of different strategies with biologics for the treatment of moderate to severe Crohn's disease in China.World journal of gastroenterology · 2026Article
- More severe natural course of Crohn's disease in Yunnan province compared with Asian and Western countries.International journal of colorectal disease · 2026Article
- Network and machine learning integration reveals gut microbiome biomarkers in pediatric IBD.BMC microbiology · 2025Article
- [Clinical application of single-balloon and double-balloon enteroscopy in pediatric small bowel diseases: a retrospective study of 576 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Gastrointestinal lymphoma in a patient on long-term azathioprine therapy: A case report with imaging features mimicking Crohn's disease.Radiology case reports · 2025Article
- Machine learning for temporary stoma after intestinal resection in surgical decision-making of Crohn's disease.BMC gastroenterology · 2025Article
- Duodenal Crohn's disease: Case report and systematic review.World journal of methodology · 2024Article
- Evaluation of Factors Contributing to Diagnosis of Crohn's Disease in the Face of Increasing Trend in Pakistan.Crohn's & colitis 360 · 2024Article
- A Shortened Diagnostic Interval and Its Associated Clinical Factors and Related Outcomes in Inflammatory Bowel Disease Patients from a Cohort Study in China.Journal of inflammation research · 2024Article
- Clinical and magnetic resonance imaging spectrum of complex perianal fistulizing Crohn's disease: A cohort study from northern India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Article
- Are We Ready to Reclassify Crohn's Disease Using Molecular Classification?Journal of clinical medicine · 2023Article
- Geographical heterogeneity in the disease characteristics and management of patients with inflammatory bowel disease, the preliminary results of a Chinese database for IBD (CHASE-IBD).Therapeutic advances in gastroenterology · 2023Article
- Expression of 5-hydroxytryptamine 7 receptor in intestinal mucosa correlates with the degree of intestinal inflammation in Crohn's disease.BMC gastroenterology · 2022Article
- Effect of smoking on the development and outcomes of inflammatory bowel disease in Taiwan: a hospital-based cohort study.Scientific reports · 2022Article
- Patients with Crohn's Disease Undergoing Abdominal Surgery: Clinical and Prognostic Evaluation Based on a Single-Center Cohort in China.World journal of surgery · 2022Observational
- Trend and Geographic Variation in Incidence and Prevalence of Inflammatory Bowel Disease in Regions Across China: A Nationwide Employee Study Between 2013 and 2016.Frontiers in medicine · 2022Article
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22 authors.
Funding
Abstract
backgroundThis study aimed to understand the disease characteristics and treatment outcomes of Crohn's disease (CD) in a real-world setting in China.
methodsIn this prospective, non-interventional, multicenter disease registry, adults (≥18 years) with existing and newly diagnosed CD were recruited from 14 medical centers across China from January 2015 to January 2017. The study consisted of the enrollment and follow-up periods, of 12 months each. Demographic, clinical characteristics, diagnostic duration and management of CD at enrollment were evaluated. Logistic regression analysis and stepwise multivariate logistic regression analysis used to assess the relationship between the risk factors and CD.
resultsOf 504 enrolled patients, 499 (99.0%) were eligible for analysis. The mean (SD) age at study enrollment was 32.3 (11.43) years and the majority (69.7%) of participants were male. In the past 15 years, a sustained decrease of the period of time in the diagnosis of CD was observed, at about 39.4 (24.11) months in 2010, which decreased to 3.1 (2.13) months in 2015. The most common presenting symptoms of CD included abdominal pain (78.0%), diarrhea (58.1%), weight loss (52.9%) and fever (30.1%). Oral ulcer (19.4%) and arthritis (9.8%) were the most common extra-intestinal manifestations. Non-stricturing non-penetrating (B1) (49.9%) behavior and ileocolonic involvement (L3) (56.2%) location were more frequent. Perianal disease was observed in 29.1% of the patients. Around 23.8% (119/499) patients had CD-related surgery other than perianal disease surgery. Older age at enrollment, longer disease course, complicated disease behavior and absence of perianal disease were all surgery risk factors (p < 0.05). The most common medications was immunomodulators (e.g., azathioprine) (41.5%), anti-TNFα agents (32.9%) and aminosalicylates (20.6%). The mean (SD) Crohn's Disease Active Index (CDAI) score was 159.1 (91.45) and almost half of the patients (49.1%, 81/165) were in remission.
conclusionsThis study demonstrated the CD-disease characteristics, risk factors of CD-related surgery and perianal disease, and treatment strategies in a real-world setting in China and may help in developing programs to diagnose and manage patients with CD.
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