ArticleBiomaterials2019
In vivo and in vitro evaluation of a biodegradable magnesium vascular stent designed by shape optimization strategy.
Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 130 citations in OpenAlex.
- State-of-the-Art Review on Finite Element Analysis Applied to Ultrathin-Strut Drug-Eluting Stents: Examining the Present and Looking Ahead to the Future.Bioengineering (Basel, Switzerland) · 2026Review
- Using Magnesium and Magnesium-Based Alloys as a Novel Biomaterial to Create Medical Devices by AM Techniques-A Review.Materials (Basel, Switzerland) · 2026Review
- Mechanically governed fracture resistance of biodegradable Zn-Cu alloy stents: Role of ring-length optimized structural design.Bioactive materials · 2026Article
- Structural Optimization and Finite Element Analysis of Variable-Stiffness Biodegradable Vascular Stents.Journal of functional biomaterials · 2026Article
- Toward Lesion-specific Stenting Strategies: A Computational Framework to Validate the Deployment of Balloon-expandable Stents.Annals of biomedical engineering · 2026Article
- Effects of molecular weight, end group of polylactide and coating thickness on corrosion rate and inhomogeneity of iron under biomimetic conditions.Regenerative biomaterials · 2026Article
- A hierarchical MgFBioactive materials · 2025Article
- Biodegradable Metal-Based Stents: Advances, Challenges, and Prospects.Journal of functional biomaterials · 2025Review
- The role of pH on structure, corrosion behavior and biocompatibility of MgFe layered double hydroxide coating on Mg-Nd-Zn-Zr alloy.Scientific reports · 2025Article
- A Structural Optimization Framework for Biodegradable Magnesium Interference Screws.Biomimetics (Basel, Switzerland) · 2025Article
- Enhancing radial strength and expansion uniformity of iron-based vascular scaffolds: a numerical and experimental investigation on topological optimization.Frontiers in bioengineering and biotechnology · 2025Article
- Manufacturing, Processing, and Characterization of Self-Expanding Metallic Stents: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2024Review
- Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration.Mechanobiology in medicine · 2024Review
- Application and Perspectives: Magnesium Materials in Bone Regeneration.ACS biomaterials science & engineering · 2024Review
- Synchrotron microtomography reveals insights into the degradation kinetics of bio-degradable coronary magnesium scaffolds.Bioactive materials · 2024Article
- Research progress of absorbable stents.International journal of medical sciences · 2024Review
- Article
- A Comparison of Vessel Patch Materials in Tetralogy of Fallot Patients Using Virtual Surgery Techniques.Annals of biomedical engineering · 2023Article
- A "built-up" composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility.Bioactive materials · 2023Article
- Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment.Bioactive materials · 2023Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
The performance of biodegradable magnesium alloy stents (BMgS) requires special attention to non-uniform residual stress distribution and stress concentration, which can accelerate localized degradation after implantation. We now report on a novel concept in stent shape optimization using a finite element method (FEM) toolkit. A Mg-Nd-Zn-Zr alloy with uniform degradation behavior served as the basis of our BMgS. Comprehensive in vitro evaluations drove stent optimization, based on observed crimping and balloon inflation performance, measurement of radial strength, and stress condition validation via microarea-XRD. Moreover, a Rapamycin-eluting polymer coating was sprayed on the prototypical BMgS to improve the corrosion resistance and release anti-hyperplasia drugs. In vivo evaluation of the optimized coated BMgS was conducted in the iliac artery of New Zealand white rabbit with quantitative coronary angiography (QCA), optical coherence tomography (OCT) and micro-CT observation at 1, 3, 5-month follow-ups. Neither thrombus or early restenosis was observed, and the coated BMgS supported the vessel effectively prior to degradation and allowed for arterial healing thereafter. The proposed shape optimization framework based on FEM provides an novel concept in stent design and in-depth understanding of how deformation history affects the biomechanical performance of BMgS. Computational analysis tools can indeed promote the development of biodegradable magnesium stents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.