ArticleBehavioural brain research2019
A role for hippocampal adult neurogenesis in shifting attention toward novel stimuli.
Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Middle aged CAMKII-Cre:CbsExperimental animals · 2024Article
- Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization.Advances in neurobiology · 2024Review
- Rewarded Maze Training Increases Approach Behavior in Rats Through Neurogenesis-Dependent Growth of Ventral Hippocampus-Prelimbic Circuits.Biological psychiatry global open science · 2023Article
- Adult-born dentate granule cells promote hippocampal population sparsity.Nature neuroscience · 2022Article
- What Is Adult Hippocampal Neurogenesis Good for?Frontiers in neuroscience · 2022Article
- A Runner's High for New Neurons? Potential Role for Endorphins in Exercise Effects on Adult Neurogenesis.Biomolecules · 2021Review
- Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis.Scientific reports · 2021Article
- Adult neurogenesis alters response to an aversive distractor in a labyrinth maze without affecting spatial learning or memory.Hippocampus · 2021Article
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
- The Effects of Anesthesia on Adult Hippocampal Neurogenesis.Frontiers in neuroscience · 2020Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
New granule neurons are born in the dentate gyrus region of the hippocampus throughout life. Behavioral effects of slowing or stopping this ongoing neurogenesis are generally observed only in complex cognitive tasks involving high levels of cue or memory interference or in tests of emotion presented after stress exposure. Here, we tested the role of new neurons in naïve rats in a simple, one-trial orienting task previously shown to be affected by hippocampal lesions. Using a pharmacogenetic method to inhibit adult neurogenesis, we found that loss of new neurons decreased orienting toward a novel auditory cue. Rats lacking new neurons showed this change in orienting only when they were drinking from a water bottle and not when they were exploring an empty arena, suggesting that the deficit is not in the ability to orient to a novel sound but in shifting of attention toward a second stimulus. Orienting was reduced to the same extent after 4 or 8 weeks of neurogenesis reduction but was not detectably altered after 2 or 3 weeks of treatment, suggesting that new neurons must mature for approximately a month before functioning in this behavior. These findings demonstrate that adult-born neurons affect behavior in a simple attention reorienting task in naïve animals with no prior stress or task-related learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.