ArticleAngewandte Chemie (International ed. in English)2019
Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti-Fungal Properties.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Structure-Activity Relationship of an All-α-helical Prenyltransferase Reveals the Mechanism of Indole Prenylation.Biochemistry · 2025Article
- Synthetic Studies toward the Aphidicolin Family of Diterpenoid Natural Products.The Journal of organic chemistry · 2025Article
- Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance.Pharmaceutics · 2024Review
- Highly chemoselective oxidative dimerization of indolosesquiterpene alkaloids: a biomimetic approach to dixiamycin.Chemical science · 2024Article
- Total synthesis of atropisomeric indolosesquiterpenoidsChemical science · 2023Article
- Total syntheses of naturally occurring antiviral indolosesquiterpene alkaloids, xiamycins C-FChemical science · 2022Article
- Strategy Evolution in a Skeletal Remodeling and C-H Functionalization-Based Synthesis of the Longiborneol Sesquiterpenoids.Journal of the American Chemical Society · 2022Article
- Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis.Frontiers in chemistry · 2022Review
- Exploring the inhibitory potential of novel bioactive compounds from mangrove actinomycetes against nsp10 the major activator of SARS-CoV-2 replication.Chemicke zvesti · 2022Article
- Enantioselective Total Synthesis of Andrographolide and 14-Hydroxy-Colladonin: Carbonyl Reductive Coupling and trans-Decalin Formation by Hydrogen Transfer.Angewandte Chemie (International ed. in English) · 2020Article
- Oxodealkenylative Cleavage of Alkene C(spAngewandte Chemie (International ed. in English) · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Divergent and enantiospecific total syntheses of the indolosesquiterpenoids xiamycins A, C, F, H and oridamycin A have been accomplished. The syntheses, which commence from (R)-carvone, employ a key photoinduced benzannulation sequence to forge the carbazole moiety characteristic of these natural products. Late-stage diversification from a common intermediate enabled the first syntheses of xiamycins C and F, and an unexpected one-pot oxidative decarboxylation, which may prove general, led to xiamycin H. All synthetic intermediates and the natural products were tested for anti-fungal activity. Xiamycin H emerged as an inhibitor of three agriculturally relevant fungal pathogens.
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