ArticleJournal of neurochemistry2020
Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology.
Article in Journal of neurochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Characterizing human endorphins with fast-scan cyclic voltammetry and carbon fiber microelectrodes.Bioelectrochemistry (Amsterdam, Netherlands) · 2026Article
- Biological and Mechanical Limitations for Chronic Fast-Scan Cyclic Voltammetry Sensor Design.Advanced materials technologies · 2025Article
- Glassy Carbon Fiber-like Multielectrode Arrays for Neurochemical Sensing and Electrophysiology Recording.Advanced materials technologies · 2025Article
- Advancing glassy carbon microelectrode arrays for neurochemical sensing: impact of double pyrolysis on structure and function.Frontiers in bioengineering and biotechnology · 2025Article
- Comparison of dopamine release and uptake parameters across sex, species and striatal subregions.The European journal of neuroscience · 2024Article
- Modulation of serotonin transporter expression by escitalopram under inflammation.Communications biology · 2024Article
- Batch Fabrication of Microelectrode Arrays with Glassy Carbon Microelectrodes and Interconnections for Neurochemical Sensing: Promises and Challenges.Micromachines · 2024Article
- Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information.Nano-micro letters · 2023Review
- Kappa Opioid Receptors Reduce Serotonin Uptake and Escitalopram Efficacy in the Mouse Substantia Nigra Pars Reticulata.International journal of molecular sciences · 2023Article
- Nano- and Microsensors for In Vivo Real-Time Electrochemical Analysis: Present and Future Perspectives.Nanomaterials (Basel, Switzerland) · 2022Review
- Novel, User-Friendly Experimental and Analysis Strategies for Fast Voltammetry: Next Generation FSCAV with Artificial Neural Networks.ACS measurement science au · 2022Article
- Article
- ROS-Scavenging Selenofluoxetine Derivatives InhibitACS omega · 2022Article
- Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens.Journal of neurophysiology · 2022Article
- Tonic Serotonin MeasurementsAnalytical chemistry · 2021Article
- Dopamine, vocalization, and astrocytes.Brain and language · 2021Article
- Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Chronic SSRI treatment reverses HIV-1 protein-mediated synaptodendritic damage.Journal of neurovirology · 2021Article
- Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.Micromachines · 2021Review
- Experimental Methods for Investigating Uptake 2 Processes In Vivo.Handbook of experimental pharmacology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
It is important to monitor serotonin neurochemistry in the context of brain disorders. Specifically, a better understanding of biophysical alterations and associated biochemical functionality within subregions of the brain will enable better of understanding of diseases such as depression. Fast voltammetric tools at carbon fiber microelectrodes provide an opportunity to make direct evoked and ambient serotonin measurements in vivo in mice. In this study, we characterize novel stimulation and measurement circuitries for serotonin analyses in brain regions relevant to psychiatric disease. Evoked and ambient serotonin in these brain areas, the CA2 region of the hippocampus and the medial prefrontal cortex, are compared to ambient and evoked serotonin in the substantia nigra pars reticulata, an area well established previously for serotonin measurements with fast voltammetry. Stimulation of a common axonal location evoked serotonin in all three brain regions. Differences are observed in the serotonin release and reuptake profiles between these three brain areas which we hypothesize to arise from tissue physiology heterogeneity around the carbon fiber microelectrodes. We validate this hypothesis mathematically and via confocal imaging. We thereby show that fast voltammetric methods can provide accurate information about local physiology and highlight implications for chemical mapping. Cover Image for this issue: doi: 10.1111/jnc.14739.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.