Evidence map›Paper›PMID 31419245›Full record

ArticlePloS one2019

Investigating the effect of lifestyle risk factors upon number of aspirated and mature oocytes in in vitro fertilization cycles: Interaction with antral follicle count.

Lana Salih Joelsson, Evangelia Elenis, Kjell Wanggren, Anna Berglund, Anastasia N Iliadou, Carolyn E Cesta, Sunni L Mumford, Richard White, Tanja Tydén, Alkistis Skalkidou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lana Salih JoelssonInstitute of Women's and Children's, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-4188-598X
Evangelia ElenisInstitute of Women's and Children's, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.
Kjell WanggrenDepartment of Clinical Science, Intervention and Technology, Obstetrics and gynecology, Karolinska Institute, Stockholm, Sweden.
Anna BerglundNational Centre for Knowledge on Men's Violence against women (NCK), Uppsala University, Uppsala, Sweden.ORCID 0000-0003-3786-7321
Anastasia N IliadouDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Carolyn E CestaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Sunni L MumfordEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.ORCID 0000-0003-0133-3176
Richard WhiteNorwegian Institute of Public Health, Oslo, Norway.
Tanja TydénInstitute of Women's and Children's, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.
Alkistis SkalkidouInstitute of Women's and Children's, Obstetrics and Gynecology, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is evidence demonstrating that certain lifestyle factors have a detrimental effect on fertility. Since such factors often coexist, possible synergistic effects merit further investigation. Thus we aimed to examine the cumulative impact of lifestyle factors on in vitro fertilization (IVF) early reproductive treatment outcomes and their interaction with measures of ovarian reserve. MATERIALS AND

methodsBy following women who were starting their first fresh IVF cycle in 2 cohorts, the "Lifestyle study cohort" (hypothesis generating cohort, n = 242) and the "UppSTART study" (validation cohort, n = 432) in Sweden, we identified two significant risk factors acting independently, smoking and BMI, and then further assessed their cumulative effects.

resultsWomen with both these risk factors had an Incidence Rate Ratio (IRR) of 0.75 [(95% CI 0.61-0.94)] regarding the number of aspirated oocytes compared to women without these risk factors. Concerning the proportion of mature oocytes in relation to the total number of aspirated oocytes, the interaction between BMI and Antral Follicle Count (AFC) was significant (p-value 0.045): the lower the value of AFC, the more harmful the effect of BMI with the outcome.

conclusionsData shows that there is an individual as well as a cumulative effect of smoking and BMI on the number of aspirated and mature oocytes in fresh IVF treatment cycles. AFC might modify associations between BMI and the proportion of mature oocytes in relation to the total number of aspirated oocytes. These results highlight the importance of lifestyle factors on IVF early reproductive outcomes and provide additional evidence for the importance of preconception guidance for the optimization of IVF cycle outcome.

Indexed as

Life StyleOvarian ReserveAdultBody Mass IndexFemaleFertilization in VitroHumansInfertilityOocyte RetrievalPreconception CareProspective StudiesRisk FactorsSmokingSweden

Identifiers

PMID31419245
PMCPMC6697332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.