Evidence map›Paper›PMID 31419116›Full record

ArticleJournal of the American Chemical Society2019

Toward a Synthetic Yeast Endosymbiont with a Minimal Genome.

Angad P Mehta, Yeonjin Ko, Lubica Supekova, Kersi Pestonjamasp, Jack Li, Peter G Schultz

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Synthesis at the Interface of Chemistry and Biology.Accounts of chemical research · 2024
    Review
  9. Article
  10. Evolution and synthetic biology.Current opinion in microbiology · 2023
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Angad P MehtaThe Department of Chemistry , Scripps Research , La Jolla , California 92037 , United States.
Yeonjin KoThe Department of Chemistry , Scripps Research , La Jolla , California 92037 , United States.
Lubica SupekovaThe Department of Chemistry , Scripps Research , La Jolla , California 92037 , United States.
Kersi PestonjamaspThe Core Microscopy Facility , Scripps Research , La Jolla , California 92037 , United States.
Jack LiThe Department of Chemistry , Scripps Research , La Jolla , California 92037 , United States.
Peter G SchultzThe Department of Chemistry , Scripps Research , La Jolla , California 92037 , United States.ORCID 0000-0003-3188-1202
Scripps Institution of Oceanography · USScripps Health · US

Funding

Experimentally Testing the Endosymbiotic Theory of Mitochondrial EvolutionR01GM132071 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHULTZ, PETER G · 2019 to 2021
$1.1M
NIGMS NIH HHS R01 GM132071
6 · The paper itself

Abstract

Based on the endosymbiotic theory, one of the key events that occurred during mitochondrial evolution was an extensive loss of nonessential genes from the protomitochondrial endosymbiont genome and transfer of some of the essential endosymbiont genes to the host nucleus. We have developed an approach to recapitulate various aspects of endosymbiont genome minimization using a synthetic system consisting of

Indexed as

SymbiosisEscherichia coliMitochondriaSaccharomyces cerevisiae

Identifiers

PMID31419116
PMCPMC6999831
OpenAlexW2967765495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.