ReviewJournal of the American Chemical Society2019
Biomedically Relevant Self-Assembled Metallacycles and Metallacages.
Review in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 361 citations in OpenAlex.
- Metal-organic macrocycles as molecular modulators of amyloid-β aggregation and cytotoxicity.Chemical science · 2026Article
- Advances in carrier-free nanodrug delivery systems.Drug delivery and translational research · 2026Review
- Low-Valent Rhodium and Iridium Assemblies Directed by Uracilate and Guaninate Linkers.Inorganic chemistry · 2026Article
- Programming Palladium Cage Geometry through Ligand Redox Modulation.Angewandte Chemie (International ed. in English) · 2026Article
- Microporous Self-Assembled Pd(II) Tetrahedral Cages for Rapid and Reversible Multi-Phase Sequestration of Iodine and Methyl Iodide.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Architecting NIR-II metal supramolecular dyes-illuminating the path to precision medicine.Chemical science · 2026Review
- Ligand Side-Chains Control the Formation of an MInorganic chemistry · 2026Article
- Selective photocatalytic oxidative cleavage of terminal alkynes to carboxylic acids within a water-soluble PdChemical science · 2026Article
- Metal-organic polyhedra maintain the self-renewal of embryonic stem cells.Nature communications · 2025Article
- Flexibility-Aided Orientational Self-Sorting and Transformations of Bioactive Homochiral Cuboctahedron PdAngewandte Chemie (International ed. in English) · 2025Article
- Article
- Self-Assembled Pd(II) Nano-Adsorbents for Iodine and Methyl Iodide Capture in Vapor and Aqueous Phases.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Exo-templating via pseudorotaxane formation reduces pathway complexity in the multicomponent self-assembly of MNature chemistry · 2025Article
- Intricate Low-Symmetry AgJournal of the American Chemical Society · 2024Article
- Assembling a new generation of radiopharmaceuticals with supramolecular theranostics.Nature reviews. Chemistry · 2024Review
- Self-Assembled Iron(III) Coordination Cage as an MRI-Active Carrier for a Gold(I) Drug.Bioconjugate chemistry · 2024Article
- Multi-Hydrogen Bonding on Quaternized-Oligourea Receptor Facilitated Its Interaction with Bacterial Cell Membranes and DNA for Broad-Spectrum Bacteria Killing.Molecules (Basel, Switzerland) · 2024Article
- Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host-Guest Complexation for Photodynamic Therapy.Nano-micro letters · 2024Article
- Naphthalene Diimide-Based Metallacage as an Artificial Ion Channel for Chloride Ion Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biomedical Applications of Sulfonylcalix[4]arene-Based Metal-Organic Supercontainers.Molecules (Basel, Switzerland) · 2024Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Diverse metal-organic complexes (MOCs), shaped as rectangles, triangles, hexagons, prisms, and cages, can be formed by coordination between metal ions (Pt, Pd, Ru, Rh, Ir, Zn, Co, and Cd) and organic ligands, with potential applications as alternatives to conventional biomedical materials for therapeutic, sensing, and imaging purposes. MOCs have been investigated as anticancer drugs in the treatment of malignant tumors in lung, cervical, breast, colon, liver, prostate, ovarian, brain, stomach, bone, skin, mouth, thyroid, and other cancers. MOCs with one, two, and three cavities have also been investigated as drug carriers and prepared for the loading and release of different drugs. In addition, MOCs can target proteins by the shape effect and recognize sugars and DNA by electrostatic interactions, as well as estradiol by host-guest interactions, etc. This Perspective mainly covers achievements in the biomedical application of MOCs. We aim to identify some key trends in the reported MOC structures in relation to their biomedical activity and potential applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.