Evidence map›Paper›PMID 31419083›Full record

ArticleMolecular genetics & genomic medicine2019

Gene-gene interaction among cell adhesion genes and risk of nonsyndromic cleft lip with or without cleft palate in Chinese case-parent trios.

Dongjing Liu, Mengying Wang, Yuan Yuan, Holger Schwender, Hong Wang, Ping Wang, Zhibo Zhou, Jing Li, Tao Wu, Hongping Zhu and 1 more

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In one paragraph

Article in Molecular genetics & genomic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Identification of a Novel Variant ofInternational journal of genomics · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongjing LiuSchool of Public Health, Peking University, Beijing, China.ORCID 0000-0002-9520-7789
Mengying WangSchool of Public Health, Peking University, Beijing, China.
Yuan YuanSchool of Public Health, Peking University, Beijing, China.
Holger SchwenderMathematical Institute, Heinrich Heine University Duesseldorf, Duesseldorf, Germany.
Hong WangSchool of Public Health, Peking University, Beijing, China.
Ping WangBeijing Center for Disease Prevention and Control, Beijing, China.
Zhibo ZhouSchool of Stomatology, Peking University, Beijing, China.
Jing LiSchool of Stomatology, Peking University, Beijing, China.
Tao WuSchool of Public Health, Peking University, Beijing, China.
Hongping ZhuSchool of Stomatology, Peking University, Beijing, China.
Terri H BeatySchool of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

International Consortium to Identify Genes and Interactions Controlling Oral ClefU01DE018993 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2007 to 2008
$1.6M
NIDCR NIH HHS U01 DE018993NIDCR NIH HHS U01-DE-018993
6 · The paper itself

Abstract

backgroundNonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with complex etiology. One strategy for studying the genetic risk factors of NSCL/P is to consider gene-gene interaction (G × G) among gene pathways having a role in craniofacial development. The present study aimed to investigate the G × G among cell adhesion gene pathway.

methodsWe carried out an interaction analysis of eight genes involved in cell adherens junctions among 806 NSCL/P Chinese case-parent trios originally recruited for a genome-wide association study (GWAS). Regression-based approach was used to test for two-way G × G interaction, while machine learning algorithm was run for exploring both two-way and multi-way interaction that may affect the risk of NSCL/P.

resultsA two-way ACTN1 × CTNNB1 interaction reached the adjusted significance level. The single nucleotide polymorphisms pair composed of rs17252114 (CTNNB1) and rs1274944 (ACTN1) yielded a p value of .0002, and this interaction was also supported by the logic regression algorithm. Higher order interactions involving ACTN1, CTNNB1, and CDH1 were picked out by logic regression, suggesting a potential role in NSCL/P risk.

conclusionThis study suggests for the first time evidence of both two-way and multi-way G × G interactions among cell adhesion genes contributing to the NSCL/P risk.

Indexed as

Epistasis, GeneticActininAntigens, CDbeta CateninCadherinsCleft LipCleft PalateHumansMachine LearningModels, GeneticPedigreePolymorphism, Single NucleotideActininACTN1 protein, humanAntigens, CDbeta CateninCadherinsCDH1 protein, humanCTNNB1 protein, humanadherens junctionscase-parent trioscell adhesiongene-gene interactionnonsyndromic cleft lip with or without cleft palate

Identifiers

PMID31419083
PMCPMC6785639

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.