Evidence map›Paper›PMID 31419045›Full record

ReviewJournal of cellular and molecular medicine2019

Long non-coding RNA expressed in macrophage co-varies with the inflammatory phenotype during macrophage development and polarization.

Yixin Xie, Min Wang, Jingjing Tian, Xianping Li, Min Yang, Kan Zhang, Shan Tan, Lingli Luo, Can Luo, Longkai Peng and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Macrophages as key modulators of calcific aortic valve disease.Frontiers in cardiovascular medicine · 2025
    Review
  2. Frontiers in immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yixin XieDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Min WangDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0002-3420-4031
Jingjing TianDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xianping LiDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Min YangDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kan ZhangDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shan TanDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lingli LuoDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Can LuoDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Longkai PengDepartment of Urological Organ Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Aiguo TangDepartment of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in microarray, RNA-seq and omics techniques, thousands of long non-coding RNAs (lncRNAs) with unknown functions have been discovered. LncRNAs have presented a diverse perspective on gene regulation in diverse biological processes, especially in human immune response. Macrophages participate in the whole phase of immune inflammatory response. They are able to shape their phenotype and arouse extensive functional activation after receiving physiological and pathological stimuli. Emerging studies indicated that lncRNAs participated in the gene regulatory network during complex biological processes of macrophage, including macrophage-induced inflammatory responses. Here, we reviewed the existing knowledges of lncRNAs in the processes of macrophage development and polarization, and their roles in several different inflammatory diseases. Specifically, we focused on how lncRNAs function in macrophage, which might help to discover some potential therapeutic targets and diagnostic biomarkers.

Indexed as

AnimalsAtherosclerosisBiomarkersCell DifferentiationCell PolarityHumansInflammationMacrophagesMonocytesMycobacterium InfectionsNeoplasmsRNA, Long NoncodingBiomarkersRNA, Long Noncodingcancerimmune responseinflammationlong non-coding RNAmacrophage polarization

Identifiers

PMID31419045
PMCPMC6787567
OpenAlexW2968067106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.