Evidence map›Paper›PMID 31418935›Full record

Trial reportClinical transplantation2019

Discharge frailty following lung transplantation.

Andrew M Courtwright, Derek Zaleski, Michael Tevald, Joe Adler, Jonathan P Singer, Edward E Cantu, Christian A Bermudez, Joshua M Diamond

Abstract readClinical Trial
In one paragraph

Trial report in Clinical transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. The Path Forward: A Review on Enhanced Recovery After Cardiothoracic Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Old Age and Frailty in Deceased Organ Transplantation and Allocation-A Plea for Geriatric Assessment and Prehabilitation.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Frailty and aging-associated syndromes in lung transplant candidates and recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew M CourtwrightPulmonary and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-9511-5975
Derek ZaleskiGood Shepard Penn Partners, Philadelphia, Pennsylvania.
Michael TevaldSchool of Health Sciences, Arcadia University, Glenside, Pennsylvania.
Joe AdlerGood Shepard Penn Partners, Philadelphia, Pennsylvania.
Jonathan P SingerPulmonary and Critical Care Medicine, University of San Francisco, San Francisco, California.ORCID 0000-0003-0224-7472
Edward E CantuCardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Christian A BermudezCardiovascular Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Joshua M DiamondPulmonary and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Funding

RESPIRATORY RESEARCHT32HL007633 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI George R Washko · 1985 to 2026
$14.9M
Frailty and patient centered outcomes in candidates for lung transplantationR01HL134851 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2017 to 2021
$3.4M
Mentored Patient Oriented Research in Lung TransplantationK24HL115354 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D · 2012 to 2021
$1.2M
Long Pentraxin-3 genomics and outcomes after lung transplantationK23HL121406 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DIAMOND, JOSHUA M. · 2014 to 2017
$629k
NHLBI NIH HHS K23 HL121406NHLBI NIH HHS K24 HL115354NHLBI NIH HHS R01 HL134851NHLBI NIH HHS T32 HL007633
6 · The paper itself

Abstract

introductionFrailty at listing for lung transplant has been associated with waitlist and post-transplant mortality. Frailty trajectories following transplant, however, have been less well characterized, including whether recipient frailty improves. The objective of this study was to identify prevalence and risk factors for frailty at discharge and to evaluate changes in frail recipients enrolled in an outpatient physical therapy program.

methodsThis was a single-center prospective cohort study of lung transplant recipients. Enrollees completed a short physical performance battery (SPPB) to assess frailty at listing and at initial hospital discharge.

resultsOf the 111 enrolled recipients, none were frail at listing and 18 (16.2%) were prefrail. At discharge, however, 60 (54.1%) patients were frail. Discharge frailty was associated with prefrailty at listing, acute kidney injury post-transplant, and longer intensive care unit stay. Among the 35 patients who were frail at discharge and who were enrolled in an outpatient PT program, the median improvement in SPPB was 6 points (IQR = 5-7 points), and 85.7% became not frail over a median of 6 weeks.

conclusionDischarge frailty is common following lung transplantation. In most frail patients, an intensive outpatient physical therapy program is associated with improvement in frailty, as assessed by the SPPB.

Indexed as

AdultFemaleFollow-Up StudiesFrailtyHumansLung TransplantationMaleMiddle AgedPatient DischargePennsylvaniaPrevalencePrognosisProspective StudiesRisk FactorsSurvival RateWaiting Listsfrailtylung transplantationphysical therapyrehabilitationshort performance physical battery

Identifiers

PMID31418935
PMCPMC6823110

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.