Evidence map›Paper›PMID 31418815›Full record

ArticleActa neurologica Scandinavica2019

Effects of comorbidity on Tourette's tic severity and quality of life.

Hilde M Huisman-van Dijk, Suzy J M A Matthijssen, Ruben T S Stockmann, Anne V Fritz, Danielle C Cath

Open access · bronzeAbstract read
In one paragraph

Article in Acta neurologica Scandinavica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

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  15. Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hilde M Huisman-van DijkDepartment of Clinical Psychology, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands.ORCID https://orcid.org/0000-0001-5297-9749
Suzy J M A MatthijssenDepartment of Clinical Psychology, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands.
Ruben T S StockmannDepartment of Clinical Psychology, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands.
Anne V FritzDepartment of Clinical Psychology, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands.
Danielle C CathRob Giel Onderzoekcentrum, Groningen, The Netherlands.
University of Applied Sciences Utrecht · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study is to gain more insight in the differential contributions of anxiety, depression and obsessive-compulsive (OC) symptom severity to quality of life (QoL) and tic severity in adults with Tourette Disorder (TD).

methodsSelf-reported OC symptom, anxiety and depression severity measures were used to investigate their predictive value on QoL and Tic severity in adult TD patients (N = 187), using correlation, regression, and mediation analyses.

resultsTic severity has no effect on QoL. Depression severity directly reduces QoL, whereas anxiety and OC symptom severity have an indirect effect on QoL, mediated by depression severity. OC symptom severity directly affects tic severity, whereas depression and anxiety severity do not have a direct effect on tic or OC severity. Finally, anxiety severity indirectly impacts tic severity, with OC symptom severity functioning as a mediator.

conclusionIn line with and extending previous studies, these findings indicate that OC symptom severity directly influences tic symptom severity whereas depression severity directly influences QoL in TD. Results imply that to improve QoL in TD patients, treatment should primarily focus on diminishing OC and depressive symptom severity rather than focusing on tic reduction.

Indexed as

Quality of LifeAdolescentAdultAnxietyChildComorbidityDepressionFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesSeverity of Illness IndexTicsTourette Syndromecomorbiditydepressionobsessive-compulsive disorderquality of lifeTourette syndrome

Identifiers

PMID31418815
PMCPMC6899939
OpenAlexW2968997628

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.