ArticleeLife2019
Enrichment drives emergence of functional columns and improves sensory coding in the whisker map in L2/3 of mouse S1.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Complex Three-Dimensional Rearing Environments Amplify Compensatory Plasticity Following Early Blindness.eNeuro · 2026Article
- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation.Nature communications · 2025Article
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- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- Article
- Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress.Frontiers in cellular neuroscience · 2025Article
- Degraded tactile coding in the Cntnap2 mouse model of autism.Cell reports · 2024Article
- Imaging the brain in action: a motorized optical rotary joint for wide field fibroscopy in freely moving animals.Neurophotonics · 2023Article
- Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex.Nature communications · 2022Article
- Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice.Neuron · 2020Article
- Effects of sleep and waking on the synaptic ultrastructure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Article
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Authors and funding
6 authors.
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Abstract
Sensory maps in layer (L) 2/3 of rodent cortex lack precise functional column boundaries, and instead exhibit locally heterogeneous (salt-and-pepper) tuning superimposed on smooth global topography. Could this organization be a byproduct of impoverished experience in laboratory housing? We compared whisker map somatotopy in L2/3 and L4 excitatory cells of somatosensory (S1) cortex in normally housed vs. tactile-enriched mice, using GCaMP6s imaging. Normally housed mice had a dispersed, salt-and-pepper whisker map in L2/3, but L4 was more topographically precise. Enrichment (P21 to P46-71) sharpened whisker tuning and decreased, but did not abolish, local tuning heterogeneity. In L2/3, enrichment strengthened and sharpened whisker point representations, and created functional boundaries of tuning similarity and noise correlations at column edges. Thus, enrichment drives emergence of functional columnar topography in S1, and reduces local tuning heterogeneity. These changes predict better touch detection by neural populations within each column.
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