ArticleeLife2019
The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Reduction of Tooth Replacement Disproportionately Affects the Evolution of Enamel Matrix Proteins.Journal of molecular evolution · 2025Article
- Resilience of the replacing dentition in adult reptiles.Developmental biology · 2024Review
- X-ray microtomography imaging of craniofacial hard tissues in selected reptile species with different types of dentition.GigaScience · 2022Article
- A "Mammalian-like" Pycnodont Fish: Independent Acquisition of Thecodont Implantation, True Vertical Replacement, and Carnassial Dentitions in Carnivorous Mammals and a Peculiar Group of Pycnodont Fish.Life (Basel, Switzerland) · 2022Article
- The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions.Science advances · 2021Article
- Article
- Role of Cell Death in Cellular Processes During Odontogenesis.Frontiers in cell and developmental biology · 2021Review
- Tooth Removal in the Leopard Gecko and theFrontiers in physiology · 2021Article
- Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition.Scientific reports · 2020Article
- The Effects of Premature Tooth Extraction and Damage on Replacement Timing in the Green Iguana.Integrative and comparative biology · 2020Article
- Grand Challenges in Comparative Tooth Biology.Integrative and comparative biology · 2020Article
- Embryonic development of skull bones in the Sahara horned viper (Cerastes cerastes), with new insights into structures related to the basicranium and braincase roof.Journal of anatomy · 2020Article
- Bargain with the tooth fairy - The savings accounts for dental stem cells.Biomedical journal · 2020Article
- Glia-Mediated Regenerative Response Following Acute Excitotoxic Damage in the Postnatal Squamate Retina.Frontiers in cell and developmental biology · 2020Article
- Sox2 maintains epithelial cell proliferation in the successional dental lamina.Cell proliferation · 2020Article
- Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary.Frontiers in cell and developmental biology · 2020Article
- Heterochronic Developmental Shifts Underlying Squamate Cerebellar Diversity Unveil the Key Features of Amniote Cerebellogenesis.Frontiers in cell and developmental biology · 2020Article
- Bite force data suggests relationship between acrodont tooth implantation and strong bite force.PeerJ · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Deep understanding of tooth regeneration is hampered by the lack of lifelong replacing oral dentition in most conventional models. Here, we show that the bearded dragon, one of the rare vertebrate species with both polyphyodont and monophyodont teeth, constitutes a key model for filling this gap, allowing direct comparison of extreme dentition types. Our developmental and high-throughput transcriptomic data of microdissected dental cells unveils the critical importance of successional dental lamina patterning, in addition to maintenance, for vertebrate tooth renewal. This patterning process happens at various levels, including directional growth but also gene expression levels, dynamics, and regionalization, and involves a large number of yet uncharacterized dental genes. Furthermore, the alternative renewal mechanism of bearded dragon dentition, with dual location of slow-cycling cells, demonstrates the importance of cell migration and functional specialization of putative epithelial stem/progenitor niches in tissue regeneration, while expanding the diversity of dental replacement strategies in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.