Evidence map›Paper›PMID 31418687›Full record

ArticleeLife2019

Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion.

Anett Dunai, Réka Spohn, Zoltán Farkas, Viktória Lázár, Ádám Györkei, Gábor Apjok, Gábor Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó and 3 more

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Sequential antibiotic exposure restores antibiotic susceptibility.The Journal of antimicrobial chemotherapy · 2025
    Article
  7. Article
  8. Article
  9. Tripartite Loops Reverse Antibiotic Resistance.Molecular biology and evolution · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anett Dunai *Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.ORCID 0000-0001-6270-9603
Réka Spohn *Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Zoltán Farkas *Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.ORCID 0000-0002-5085-3306
Viktória LázárSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Ádám GyörkeiSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Gábor ApjokSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Gábor BorossSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.ORCID 0000-0002-7208-5678
Balázs SzappanosSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Gábor GrézalSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Anikó FaragóDoctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
László BodaiDepartment of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary.ORCID 0000-0001-8411-626X
Balázs PappSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
Csaba PálSynthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.ORCID 0000-0002-5187-9903

Funding

Gazdaságfejlesztési és Innovációs Operatív Programm GINOP-2.3.2-15-2016-00014Gazdaságfejlesztési és Innovációs Operatív Programm GINOP-2.3.2-15-2016-00020Gazdaságfejlesztési és Innovációs Operatív Programm GINOP-2.3.2-15-2016-00026H2020 European Research Council H2020-ERC-2014-CoG 648364 - Resistance EvolutionHungarian Academy of Sciences Momentum Programme LP-2017-10/2017Magyar Tudományos Akadémia Lendület Programme LP2009-013/2012Magyar Tudományos Akadémia Lendület Programme LP 2012-32/2018Magyar Tudományos Akadémia Postdoctoral Programme PD-007/2016Magyar Tudományos Akadémia Postdoctoral Programme PD-038/2015Momentum Programme of the Hungarian Academy of Sciences LP-2017-10/2017National Research, Development and Innovation Office Élvonal Programme KKP 126506National Research, Development and Innovation Office FK 128775National Research, Development and Innovation Office NKFI-112294Wellcome Trust WT 084314/Z/07/ZWellcome Trust WT 098016/Z/11/Z
6 · The paper itself

Abstract

Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of resistance may proceed too slowly to be of practical importance. We present our study on the efficacy and phenotypic impact of compensatory evolution in

Indexed as

Adaptation, BiologicalDrug Resistance, BacterialGenotypePhenotypeAnti-Bacterial AgentsCulture MediaEscherichia coliTime FactorsAnti-Bacterial AgentsCulture Mediaantibiotic resistancecompensatory mutationsE. colievolutionevolutionary biology

Identifiers

PMID31418687
PMCPMC6707769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.