Evidence map›Paper›PMID 31418609›Full record

SynthesisOcular immunology and inflammation2020

Instrument-based Tests for Measuring Anterior Chamber Cells in Uveitis: A Systematic Review.

Xiaoxuan Liu, Ameenat L Solebo, Livia Faes, Sophie Beese, Tasanee Braithwaite, Matthew E Round, Jesse Panthagani, Aditya U Kale, Thomas W McNally, Didar Abdulla and 3 more

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Ocular immunology and inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. OCT Assisted Quantification of Vitreous Inflammation in Uveitis.Translational vision science & technology · 2022
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Xiaoxuan LiuAcademic Unit of Ophthalmology, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.ORCID https://orcid.org/0000-0002-1286-0038
Ameenat L SoleboNIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology , London, UK.
Livia FaesNIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology , London, UK.
Sophie BeeseInstitute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
Tasanee BraithwaiteOphthalmology Department, University Hospitals Birmingham NHS Foundation Trust , Birmingham, UK.
Matthew E RoundSandwell and West Birmingham Hospitals NHS Trust , Birmingham, UK.
Jesse PanthaganiOphthalmology Department, University Hospitals Birmingham NHS Foundation Trust , Birmingham, UK.
Aditya U KaleAcademic Unit of Ophthalmology, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
Thomas W McNallyAcademic Unit of Ophthalmology, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
Didar AbdullaOphthalmology Department, University Hospitals Birmingham NHS Foundation Trust , Birmingham, UK.
Pearse A KeaneNIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology , London, UK.
David J MooreInstitute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.
Alastair K DennistonAcademic Unit of Ophthalmology, Institute of Inflammation & Ageing, College of Medical and Dental Sciences, University of Birmingham , Birmingham, UK.ORCID https://orcid.org/0000-0001-7849-0087
University Hospitals Birmingham NHS Foundation Trust · GBMoorfields Eye Hospital NHS Foundation Trust · GBUniversity of Birmingham · GBSandwell & West Birmingham Hospitals NHS Trust · GB

Funding

Department of Health CS-2014-14-023Department of Health CS-2018-18-ST2-005Medical Research Council MC_PC_17183Wellcome Trust 200141/Z/15/Z
6 · The paper itself

Abstract

purposeNew instrument-based techniques for anterior chamber (AC) cell counting can offer automation and objectivity above clinician assessment. This review aims to identify such instruments and its correlation with clinician estimates.

methodsUsing standard systematic review methodology, we identified and tabulated the outcomes of studies reporting reliability and correlation between instrument-based measurements and clinician AC cell grading.

resultsFrom 3470 studies, 6 reported correlation between an instrument-based AC cell count to clinician grading. The two instruments were optical coherence tomography (OCT) and laser flare-cell photometry (LFCP). Correlation between clinician grading and LFCP was 0.66-0.87 and 0.06-0.97 between clinician grading and OCT. OCT volume scans demonstrated correlation between 0.75 and 0.78. Line scans in the middle AC demonstrated higher correlation (0.73-0.97) than in the inferior AC (0.06-0.56).

conclusionAC cell count by OCT and LFP can achieve high levels of correlation with clinician grading, whilst offering additional advantages of speed, automation, and objectivity.

Indexed as

Anterior ChamberCell CountHumansPhotometryTomography, Optical CoherenceUveitisAnterior chamber cellsaqueous humoraqueous humourdiagnostic testlaser flare-cell photometryoptical coherence tomographysystematic reviewuveitis

Identifiers

PMID31418609
PMCPMC7497279
OpenAlexW2969126940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.