Evidence map›Paper›PMID 31418415›Full record

ArticleThe Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2019

A significant upsurge of body mass index in patients with chronic hepatitis C successfully treated with direct-acting antiviral regimens.

Mohamed El Kassas, Mohamed Alboraie, Mervat Naguib, Heba Omar, Adel El Tahan, Inas Moaz, Mohamed Abdellah, Sameera Ezzat, Mohamed-Naguib Wifi, Ahmed F Sherief and 4 more

Open access · bronzeAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Mohamed El KassasEndemic Medicine Department, Helwan University School of Medicine, Cairo, Egypt.
Mohamed AlboraieDepartment of Internal Medicine and and Hepatogastroenterology Unit, Al-Azhar University, Cairo, Egypt.
Mervat NaguibInternal Medicine Department, Cairo University School of Medicine, Cairo, Egypt.
Heba OmarEndemic Medicine and Hepato-Gastroenterology Department, Cairo University School of Medicine, Cairo, Egypt.
Adel El TahanNew Cairo Viral Hepatitis Treatment Unit, Cairo, Egypt.
Inas MoazEpidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.
Mohamed AbdellahDepartment of Internal Medicine and and Hepatogastroenterology Unit, Al-Azhar University, Cairo, Egypt.
Sameera EzzatEpidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Shebin Elkom, Egypt.
Mohamed-Naguib WifiInternal Medicine Department, Cairo University School of Medicine, Cairo, Egypt.
Ahmed F SheriefTropical Medicine Department, Ain Shams University School of Medicine, Cairo, Egypt.
Mohamed EltabbakhTropical Medicine Department, Ain Shams University School of Medicine, Cairo, Egypt.
Lobna AbdelsalamDepartment of Clinical - Chemical Pathology, Cairo University School of Medicine, Cairo, Egypt.
Amal H EissaClinical Pathology Department, Helwan University School of Medicine, Cairo, Egypt.
Dalia OmranEndemic Medicine and Hepato-Gastroenterology Department, Cairo University School of Medicine, Cairo, Egypt.
Cairo University · EGAin Shams University · EGAl-Azhar University · EGHelwan University · EGMenoufia University · EGNew Cairo Academy · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThere is less data regarding the changes in body mass index (BMI) after treating hepatitis C virus (HCV) patients with new direct-acting antiviral agents (DAAs). This study aimed to assess the changes in BMI in chronic HCV patients treated with DAAs in Egypt and to explore other factors influencing this change. MATERIALS AND

methodsThe data of chronic HCV patients who received antiviral therapy with new DAAs in one of Egypt's specialized viral hepatitis treatment centers were retrospectively analyzed. In addition to the routine clinical and laboratory workup, changes in body weight during and after treatment were monitored and BMI was calculated. Viral load was measured at 12 weeks post-treatment to assess a sustained virological response. Patients with documented thyroid abnormalities, bariatric surgery, or ensuing special diets were excluded. BMI of >30 was taken as the cutoff for pa¬tients with obesity.

resultsThe study included 162 patients with a mean age of 48.56±11.49 years, of whom 61.1% were males, 16% were treatment-experienced, 12% were diabetic, and 29% were obese. Treatment duration was 12 weeks in 84% of patients and 24 weeks in 16% of patients. There was a significant increase in BMI post-treatment as compared to pretreatment measures (28.68±5.35 vs 28.18±4.55) (p=0.03). BMI changes were constant regardless of cirrhosis or previous treatment experience.

conclusionTreatment of chronic HCV with DAAs was associated with increased body mass index. Further studies are needed to explore if this effect is secondary to treatment with DAAs or is an improvement in the liver function and lifestyle of treated patients.

Indexed as

Body Mass IndexHepacivirusAdultAntiviral AgentsBody WeightFemaleHepatitis C, ChronicHumansMaleMiddle AgedRetrospective StudiesSustained Virologic ResponseAntiviral Agents

Identifiers

PMID31418415
PMCPMC6699564
OpenAlexW2967714003

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.