Evidence map›Paper›PMID 31418117›Full record

ArticleAnnals of intensive care2019

Initial management of diabetic ketoacidosis and prognosis according to diabetes type: a French multicentre observational retrospective study.

Adrien Balmier, Fadia Dib, Arnaud Serret-Larmande, Etienne De Montmollin, Victorine Pouyet, Benjamin Sztrymf, Bruno Megarbane, Abirami Thiagarajah, Didier Dreyfuss, Jean-Damien Ricard and 1 more

Open access · goldAbstract read
In one paragraph

Article in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Adrien BalmierIntensive Care Unit, Louis Mourier Hospital, AP-HP, 178 rue des Renouillers, 92700, Colombes, France.
Fadia DibINSERM, CIC 1417, F-CRIN, I-REIVAC, Paris, France.
Arnaud Serret-LarmandeDepartment of Epidemiology, Biostatistics and Clinical Research, Bichat-Claude-Bernard Hospital, Université de Paris, AP-HP, 75018, Paris, France.
Etienne De MontmollinIntensive Care Unit, Centre Hospitalier de Saint-Denis, Hopital Delafontaine, 93205, Saint Denis, France.
Victorine PouyetIntensive Care Unit, Hôpital René-Dubos, 95300, Pontoise, France.
Benjamin SztrymfService de Réanimation polyvalente et surveillance continue, Université Paris Sud, Hôpital Antoine Béclère, AP-HP, 92400, Clamart, France.
Bruno MegarbaneDepartment of Medical and Toxicological Critical Care, Lariboisière Hospital, AP-HP, Université de Paris, 75010, Paris, France.
Abirami ThiagarajahIntensive Care Unit, Louis Mourier Hospital, AP-HP, 178 rue des Renouillers, 92700, Colombes, France.
Didier DreyfussIntensive Care Unit, Louis Mourier Hospital, AP-HP, 178 rue des Renouillers, 92700, Colombes, France.
Jean-Damien RicardIntensive Care Unit, Louis Mourier Hospital, AP-HP, 178 rue des Renouillers, 92700, Colombes, France.
Damien RouxIntensive Care Unit, Louis Mourier Hospital, AP-HP, 178 rue des Renouillers, 92700, Colombes, France. damien.roux@aphp.fr.ORCID http://orcid.org/0000-0002-6103-6416
Inserm · FRUniversité Claude Bernard Lyon 1 · FRCentre Hospitalier René-Dubos · FRHôpital Louis-Mourier · FRUniversité Paris-Sud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGuidelines for the management of diabetic ketoacidosis (DKA) do not consider the type of underlying diabetes. We aimed to compare the occurrence of metabolic adverse events and the recovery time for DKA according to diabetes type.

methodsMulticentre retrospective study conducted at five adult intermediate and intensive care units in Paris and its suburbs, France. All patients admitted for DKA between 2013 and 2014 were included. Patients were grouped and compared according to the underlying type of diabetes into three groups: type 1 diabetes, type 2 or secondary diabetes, and DKA as the first presentation of diabetes. Outcomes of interest were the rate of metabolic complications (hypoglycaemia or hypokalaemia) and the recovery time.

resultsOf 122 patients, 60 (49.2%) had type 1 diabetes, 28 (22.9%) had type 2 or secondary diabetes and 34 (27.9%) presented with DKA as the first presentation of diabetes (newly diagnosed diabetes). Despite having received lower insulin doses, hypoglycaemia was more frequent in patients with type 1 diabetes (76.9%) than in patients with type 2 or secondary diabetes (50.0%) and in patients with newly diagnosed diabetes (54.6%) (p = 0.026). In contrast, hypokalaemia was more frequent in the latter group (82.4%) than in patients with type 1 diabetes (57.6%) and type 2 or secondary diabetes (51.9%) (p = 0.022). The median recovery times were not significantly different between groups.

conclusionsRates of metabolic complications associated with DKA treatment differ significantly according to underlying type of diabetes. Decreasing insulin dose may limit those complications. DKA treatment recommendations should take into account the type of diabetes.

Indexed as

Critical careDiabetic ketoacidosisHypoglycaemiaHypokalaemiaInsulinType 1 diabetesType 2 diabetes

Identifiers

PMID31418117
PMCPMC6695456
OpenAlexW2967084704

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.