ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
Increased epicardial fat thickness and carotid intima-media thickness in migraine patients.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Investigation of the subclinical atherosclerosis risk in patients with migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Comment on "Increased Epicardial Fat Thickness and Carotid Intima-Media Thickness in Migraine Patients".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Migraine without Aura and Subclinical Atherosclerosis in Young Females: Is Gut Microbiota to Blame?Medicina (Kaunas, Lithuania) · 2019Observational
- Echocardiographic epicardial fat thickness and immature granulocyte are novel inflammatory predictors of acute ischemic stroke: a prospective study.Sao Paulo medical journal = Revista paulista de medicinaArticle
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2 authors at 1 institution in 1 country.
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Abstract
backgroundMigraine is a common and debilitating neurological disorder characterized with episodic attacks. Epicardial fat is metabolically active and is an important predictor of metabolic and vascular diseases. We aimed to examine whether the echocardiographic measurement of epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) is increased in patients with episodic migraine (EM).
methodsWe studied 96 volunteers, including 48 patients with EM (mean age 40.10 ± 10 years, 41 female patients) and 48 healthy subjects (mean age 42.69 ± 10 years, gender is the same). All necessary biochemical parameters were analyzed; subsequently, EFT and CIMT were measured in all subjects. The migraine characteristics of the patients were questioned in detail.
resultsThe patients with EM had a significantly higher EFT than the control group (5.34 ± 1.02 vs. 4.41 ± 0.68; P < 0.001) and CIMT was also found to be high (median 6.70 vs. 5.60; P < 0.001). Furthermore, there was a positive correlation between EFT and duration of disease and monthly frequency (r = 0.730; P < 0.001). EFT was significantly correlated with CIMT in the migraineurs (P < 0.001). As an optimal cut-off point, a high-risk EFT value of 5.54 mm was determined to predict EM, with 58.3% sensitivity and 96.8% specificity.
conclusionWe found that EFT and CIMT were significantly higher in EM patients than in healthy individuals. Increased EFT may be a new risk factor in migraine patients especially in patients with increased pain frequency.
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