Evidence map›Paper›PMID 31418112›Full record

ArticleParasitology research2019

Immunodiagnosis of human neurocysticercosis: comparative performance of serum diagnostic tests in Mexico.

Marisela Hernández, Osvaldo-Germán Astudillo, Gustavo Diego, Jorge-Luis de-la-Rosa-Arana, Antonio Meza-Lucas, Ricardo García-Rodea, Matthew-L Romo, Andrea Toledo, R-Michael-E Parkhouse, Teresa Garate and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Parasitology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Article
  6. Review
  7. Article
  8. CystiHuman: A model of human neurocysticercosis.PLoS computational biology · 2022
    Article
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Marisela HernándezDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico.
Osvaldo-Germán AstudilloAdministración Nacional de Laboratorios e Institutos de Salud (ANLIS) "Dr. Carlos Malbrán", Buenos Aires, Argentina.
Gustavo DiegoAdministración Nacional de Laboratorios e Institutos de Salud (ANLIS) "Dr. Carlos Malbrán", Buenos Aires, Argentina.
Jorge-Luis de-la-Rosa-AranaInstituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Secretaria de Salud, Ciudad de México, Mexico.
Antonio Meza-LucasInstituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Secretaria de Salud, Ciudad de México, Mexico.
Ricardo García-RodeaInstituto de Diagnóstico y Referencia Epidemiológicos (InDRE), Secretaria de Salud, Ciudad de México, Mexico.
Matthew-L RomoSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, Hong Kong.
Andrea ToledoUnidad de Neuroinflamación, Instituto de Investigaciones Biomédicas-UNAM/Instituto Nacional de Neurología y Neurocirugía/Facultad de Medicina-UNAM, Ciudad de México, Mexico.
R-Michael-E ParkhouseInstituto Gulbenkian de Ciência (IGC), Lisbon, Portugal.
Teresa GarateInstituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Edda SciuttoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico.
Agnès FleuryUnidad de Neuroinflamación, Instituto de Investigaciones Biomédicas-UNAM/Instituto Nacional de Neurología y Neurocirugía/Facultad de Medicina-UNAM, Ciudad de México, Mexico. afleury@biomedicas.unam.mx.ORCID http://orcid.org/0000-0002-8930-2202
Secretaria de Salud · MXAdministración Nacional de Laboratorios e Institutos de Salud · ARInstituto Nacional de Neurología y Neurocirugía · MXUniversidad Nacional Autónoma de México · MXInstituto de Salud Carlos III · ESInstituto Gulbenkian de Ciência · PTUniversity of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunodiagnosis has a supportive role in the diagnosis of neurocysticercosis (NCC). The aim of this study was to compare the validity of seven immunodiagnostic tests among serum samples from 58 patients with NCC, 26 patients with neurological diseases other than NCC, and 15 healthy controls. One test for viable parasite detection (HP10 antigen assay) and six for antibody detection were evaluated. For the entire sample, sensitivities ranged from 55.2% (NOVALISA) to 81.0% (enzyme-linked immunosorbent assay [ELISA] Taenia solium antibody), with the sensitivity of the latter test significantly higher than that of the in-house ELISA Taenia crassiceps, NOVALISA, enzyme-linked immunoelectrotransfer blot (EITB) CDC, and HP10. Overall, specificities were high, ranging from 85.4% (ELISA Ts) to 97.1% (NOVALISA), with no statistically significant differences. Detection of HP10 antigen was significantly associated with the presence of vesicular parasites. The simple and low-cost ELISA Taenia solium antibody Ab instead of EITB is recommended to support NCC diagnosis in both rural and hospital settings in Mexico.

Indexed as

AdultAnimalsAntibodies, HelminthAntigens, HelminthDiagnostic Tests, RoutineEnzyme-Linked Immunosorbent AssayFemaleHumansImmunologic TestsMaleMexicoNeurocysticercosisRural PopulationSensitivity and SpecificityTaenia soliumAntibodies, HelminthAntigens, HelminthEITBELISAHP10ImmunodiagnosisMexicoNeurocysticercosis

Identifiers

PMID31418112
OpenAlexW2967686586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.