ReviewAnnals of intensive care2019
Diagnosis and management of metabolic acidosis: guidelines from a French expert panel.
Review in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Label Pilot Study Using Hydroxytyrosol (HT) as a Dietary Supplement in Patients With Mitochondrial Diseases (MDs)
Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload
Who cites it
40 citing papers in PubMed, 103 citations in OpenAlex.
- Severe Pediatric Diabetic Ketoacidosis Complicated by Dialysis-Requiring Acute Tubular Injury, in a Child Newly Diagnosed with Type 1 Diabetes Mellitus: A Case Report.Reports (MDPI) · 2026Article
- Atypical Presentation of Gastric Perforation in an Octogenarian Masquerading as a Near-Fall: A Case Report.Cureus · 2026Article
- Factors associated with acute kidney injury in rhabdomyolysis: Insights from a prospective study.World journal of nephrology · 2026Article
- Association of preoperative albumin-corrected anion gap with 28-day mortality in cardiac surgery patients: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Clinical Implications of Low Anion Gap in Critically Ill Patients: Insights from the BOLD Multi-Centre Blood Gas Dataset.Maedica · 2026Article
- Increased serum albumin corrected anion gap levels are associated with poor prognosis in sepsis-induced coagulopathy patients.PloS one · 2026Article
- Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.Frontiers in oncology · 2026Article
- Short piece: metabolic acidosis.Intensive care medicine · 2025Article
- Clinical value of albumin-corrected anion gap combined with lactate dehydrogenase in predicting sepsis-associated liver injury in children: a single-center retrospective cohort study.BMC pediatrics · 2025Article
- The pH-Dependent Specificity of Cathepsin S and Its Implications for Inflammatory Communications and Disease.Biochemistry · 2025Article
- Open-label pilot study using hydroxytyrosol as dietary supplements in patients with mitochondrial diseases.Orphanet journal of rare diseases · 2025Article
- Article
- Article
- Prevalence of a delayed diagnosis of caffeine poisoning in the emergency department of a Japanese hospital.Journal of general and family medicine · 2025Article
- Albumin corrected anion gap and clinical outcomes in elderly patients with acute kidney injury caused or accompanied by sepsis: a MIMIC-IV retrospective study.European journal of medical research · 2025Article
- Article
- Association between changes in corrected anion gap and mortality among critically ill patients during ICU stay: a multicenter observational study.Frontiers in physiology · 2025Article
- Complexities, Benefits, Risks, and Clinical Implications of Sodium Bicarbonate Administration in Critically Ill Patients: A State-of-the-Art Review.Journal of clinical medicine · 2024Review
- Management of diabetic keto-acidosis in adult patients admitted to intensive care unit: an ESICM-endorsed international survey.Critical care (London, England) · 2024Article
- Association between serum anion gap and 28-day mortality in critically ill patients with infective endocarditis: a retrospective cohort study from MIMIC IV database.BMC cardiovascular disorders · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic acidosis is a disorder frequently encountered in emergency medicine and intensive care medicine. As literature has been enriched with new data concerning the management of metabolic acidosis, the French Intensive Care Society (Société de Réanimation de Langue Française [SRLF]) and the French Emergency Medicine Society (Société Française de Médecine d'Urgence [SFMU]) have developed formalized recommendations from experts using the GRADE methodology. The fields of diagnostic strategy, patient assessment, and referral and therapeutic management were addressed and 29 recommendations were made: 4 recommendations were strong (Grade 1), 10 were weak (Grade 2), and 15 were experts' opinions. A strong agreement from voting participants was obtained for all recommendations. The application of Henderson-Hasselbalch and Stewart methods for the diagnosis of the metabolic acidosis mechanism is discussed and a diagnostic algorithm is proposed. The use of ketosis and venous and capillary lactatemia is also treated. The value of pH, lactatemia, and its kinetics for the referral of patients in pre-hospital and emergency departments is considered. Finally, the modalities of insulin therapy during diabetic ketoacidosis, the indications for sodium bicarbonate infusion and extra-renal purification as well as the modalities of mechanical ventilation during severe metabolic acidosis are addressed in therapeutic management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.