ArticleInternational urogynecology journal2020
New Zealand white rabbit: a novel model for prolapse mesh implantation via a lumbar colpopexy.
Article in International urogynecology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Chapter 4.5: New Proposed Treatments for Pelvic Organ Prolapse.International urogynecology journal · 2026Review
- Exosome injection as a prevention strategy for early postoperative mesh complications in a porcine model of sacrocolpopexy.NPJ Regenerative medicine · 2025Article
- Developing a procedure mimicking transvaginal mesh implantation in women in a modified POP rat model.Frontiers in medicine · 2025Article
- Vaginal host response to polycarbonate urethane, an alternative material for the repair of pelvic organ prolapse.Acta biomaterialia · 2024Article
- The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse.International urogynecology journal · 2024Review
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- Advances in vaginal bioengineering: Applications, techniques, and needs.Current research in physiology · 2023Review
- Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo.Acta biomaterialia · 2022Article
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- A soft elastomer alternative to polypropylene for pelvic organ prolapse repair: a preliminary study.International urogynecology journal · 2022Article
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introduction and hypothesisNew Zealand white rabbits are an inexpensive large-animal model. This study explored the rabbit as a model for mesh-augmented colpopexy using the intra-abdominal vagina. We hypothesized that polypropylene mesh would negatively impact rabbit vaginal smooth muscle (VSM) morphology and contractile function, similar to the nonhuman primate (NHP)-the established model for prolapse mesh evaluation.
methodsRestorelle was implanted onto the vagina of ten rabbits via lumbar colpopexy after a hysterectomy. Ten rabbits served as sham. Twelve weeks post-implantation, the vagina was excised and VSM morphology and vaginal contractility were assessed. Outcome measures were compared using independent samples t and Mann-Whitney U tests with a Bonferroni correction, where appropriate. Results from the rabbits were compared with published NHP data.
resultsAnimals had similar age, parity and BMI. VSM was 18% thinner after Restorelle implantation, P = 0.027. Vaginal contractility was 43% decreased in response to 120 mM KCl (P = 0.003), similar to the 46% reduction observed in the NHP vagina implanted with Restorelle (P = 0.027). Three meshes wrinkled in vivo, resulting in dramatic thinning of the underlying vagina in the area of the mesh causing a mesh exposure.
conclusionsPolypropylene mesh negatively impacts VSM morphology and vaginal contractility in the rabbit, similar to the NHP, suggesting that the rabbit may serve as an alternative large-animal model. The vaginal thinning and appearance of a mesh exposure in the area of a mesh wrinkle suggest the rabbit may also serve as a model for understanding the pathophysiology of mesh exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.