ReviewFrontiers in bioengineering and biotechnology2019
Mechanisms of Adverse Local Tissue Reactions to Hip Implants.
Review in Frontiers in bioengineering and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Correlation and diagnostic performance of metal ions in patients with pseudotumor after MoM hip arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Metallosis Following Total Hip Arthroplasty: A Case Report.Journal of orthopaedic case reports · 2026Article
- Review
- Inflammatory Pseudotumor After Total Hip Arthroplasty-An Increasingly Recognized Complication.Orthopaedic surgery · 2026Review
- [Robotics in modern total hip arthroplasty: personalized implantation strategies for complex conditions : Optimization of primary total hip arthroplasty using image-based robotic assistance].Orthopadie (Heidelberg, Germany) · 2026Article
- Case Report: Pseudotumor due to Trunnionosis in Ceramic-on-Ceramic THA Monoblock Acetabular Cup Disengagement.Case reports in orthopedics · 2026Article
- Kinetics and Fluid-Specific Behavior of Metal Ions After Hip Replacement.Bioengineering (Basel, Switzerland) · 2025Article
- The Effect of Implant Size on Fretting Currents of Acetabular Cup-Liner Tapers During in Vitro Cyclic Loading.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Establishing the Frequency of the HLA Class II Pseudotumour 'at Risk' Genotype: A Pilot Epidemiologic Analysis.ANZ journal of surgery · 2025Article
- Evaluating the potential hepatotoxicity from hip implant wear products-AnBiomaterials and biosystems · 2025Article
- A Comprehensive Literature Review of Total Hip Arthroplasty (THA): Part 1-Biomaterials.Journal of functional biomaterials · 2025Review
- A Case Report on a Fractured Ceramic Bearing Surface Following Total Hip Replacement and a Short Review on the Mechanisms of Liner Fracture.Reports (MDPI) · 2024Article
- Blood Metal Ion Levels After Hip Resurfacing: A Comparison of 2 Different Implants.Arthroplasty today · 2024Article
- Review
- Cobalt ions induce a cellular senescence secretory phenotype in human synovial fibroblast-like cells that may be an early event in the development of adverse local tissue reactions to hip implants.Osteoarthritis and cartilage open · 2024Article
- Association between metallic implants and stroke in US adults from NHANES 2015-2023 a cross-sectional study.Frontiers in aging neuroscience · 2024Article
- Adverse Local Tissue Reaction Secondary to Corrosion at Multiple Junctions in a Modular, Segmental, Distal Femoral Replacement.Arthroplasty today · 2023Article
- Wear debris in metal-on-metal bearings and modular junctions : What have we learned from the last decades?Orthopadie (Heidelberg, Germany) · 2023Review
- Osteosarcoma Around a Ceramic-on-Ceramic Total Hip Arthroplasty.Arthroplasty today · 2023Article
- Radiation impacts on toxicity of cobalt-chromium (CoCr) implant debris.Nanotoxicology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse Local Tissue Reactions (ALTRs) are one of the main causes of hip implant failures. Although the metal release from the implants is considered as a main etiology, the mechanisms, and the roles of the released products are topics of ongoing research. The alloys used in the hip implants are considered biocompatible and show negligible corrosion in the body environment under static conditions. However, modularity and its associated mechanically assisted corrosion have been shown to release metal species into the body fluids. ALTRs associated with metal release have been observed in hip implants with metal-on-metal articulation initially, and later with metal-on-polyethylene articulation, the most commonly used design in current hip replacement. The etiological factors in ALTRs have been the topics of many studies. One commonly accepted theory is that the interactions between the metal species and body proteins and cells generate a delayed type IV hypersensitivity reaction leading to ALTRs. However, lymphocyte reactions are not always observed in ALTRS, and the molecular mechanisms have not been clearly demonstrated. A more accepted mechanism is that cell damage generated by metal ions may trigger the secretion of cytokines leading to the inflammatory reactions observed in ALTRs. In this inflammatory environment, some patients would develop hypersensitivity that is associated with poor outcomes. Concerns over ALTRS have brought significant impact to both the clinical selection and development of hip implants. This review is focused on the mechanisms of ALTRs, specifically, the metal release process and the roles of the metal species released in the etiology and pathogenesis of the disease. Hopefully, our presentation and discussion of this biological process from a material perspective could improve our current understanding on the ALTRs and provide useful guidance in developing preventive solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.