ArticleFrontiers in chemistry2019
A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications.
Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- A Novel Adductomics Workflow IncorporatingEnvironmental science & technology · 2024Article
- Bottom-up proteomics analysis for adduction of the broad-spectrum herbicide atrazine to histone.Analytical and bioanalytical chemistry · 2023Article
- Dereplication of antimicrobial biosurfactants from marine bacteria using molecular networking.Scientific reports · 2021Article
- Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
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Abstract
Identification of protein covalent modifications (adducts) is a challenging task mainly due to the lack of data processing approaches for adductomics studies. Despite the huge technological advances in mass spectrometry (MS) instrumentation and bioinformatics tools for proteomics studies, these methodologies have very limited success on the identification of low abundant protein adducts. Herein we report a novel strategy inspired on the metabolomics workflows for the identification of covalently-modified peptides that consists on LC-MS data preprocessing followed by statistical analysis. The usefulness of this strategy was evaluated using experimental LC-MS data of histones isolated from HepG2 and THLE2 cells exposed to the chemical carcinogen glycidamide. LC-MS data was preprocessed using the open-source software MZmine and potential adducts were selected based on the
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