Evidence map›Paper›PMID 31417552›Full record

ArticleFrontiers in immunology2019

Vitamin D Regulates the Microbiota to Control the Numbers of RORγt/FoxP3+ Regulatory T Cells in the Colon.

Margherita T Cantorna, Yang-Ding Lin, Juhi Arora, Stephanie Bora, Yuan Tian, Robert G Nichols, Andrew D Patterson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Impacts of microplastics on gut health: Current status and future directions.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Pooled it
  2. Pooled it
  3. Gut distress and interventionFrontiers in public health · 2023
    Pooled it
  4. Trial
  5. Review
  6. Review
  7. [Interpretation of the Expert Consensus Statement on the Role of Vitamin D in Metabolic Health].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Vitamin D ImprovesInfection and drug resistance · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Two lineages of immune cells that differentially express the vitamin D receptor.The Journal of steroid biochemistry and molecular biology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Margherita T CantornaDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Yang-Ding LinDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Juhi AroraDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Stephanie BoraDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Yuan TianDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Robert G NicholsDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Andrew D PattersonDepartment of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · USChinese Academy of Sciences · CN

Funding

Vitamin D Fluctuations and the Mucosal Immune ResponseR01AT005378 · NCCIH · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T · 2009 to 2020
$4.1M
NCCIH NIH HHS R01 AT005378
6 · The paper itself

Abstract

The active form of vitamin D (1,25(OH)

Indexed as

ColitisColonGastrointestinal MicrobiomeAnimalsBacteroidetesCalcitriolClostridiumForkhead Transcription FactorsMiceNuclear Receptor Subfamily 1, Group F, Member 3T-Lymphocytes, RegulatoryCalcitriolForkhead Transcription FactorsFoxp3 protein, mouseNuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mousegnotobiotic miceinflammatory bowel diseasesmicrobiotaT regulatory (T reg) cellsvitamin D

Identifiers

PMID31417552
PMCPMC6682671
OpenAlexW2961206609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.