Evidence map›Paper›PMID 31417546›Full record

ArticleFrontiers in immunology2019

Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.

Chengfei Wu, Li-Long Pan, Wenying Niu, Xin Fang, Wenjie Liang, Jiahong Li, Hongli Li, Xiaohua Pan, Wei Chen, Hao Zhang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Article
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  11. Article
  12. Development of Functional Kiwifruit Jelly withFoods (Basel, Switzerland) · 2022
    Article
  13. Review
  14. Review
  15. The impact of dietary fibers onFrontiers in cellular and infection microbiology · 2022
    Article
  16. The Impact of Intestinal Microorganisms and Their Metabolites on Type 1 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
  17. NOD-like receptors in autoimmune diseases.Acta pharmacologica Sinica · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Chengfei WuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Li-Long PanSchool of Medicine, Jiangnan University, Wuxi, China.
Wenying NiuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Xin FangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Wenjie LiangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Jiahong LiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Hongli LiState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Xiaohua PanState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Jonathan R T LakeyDepartment of Surgery, University of California, Irvine, Orange, CA, United States.
Birgitta AgerberthDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital, Huddinge, Sweden.
Paul de VosDivision of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Jia SunState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Jiangnan University · CNState Key Laboratory of Food Science and Technology · CNKarolinska Institutet · SEUniversity of California, Irvine · USUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal homeostasis underpins the development of type 1 diabetes (T1D), and dietary manipulations to enhance intestinal homeostasis have been proposed to prevent T1D. The current study aimed to investigate the efficacy of supplementing a novel specific low-methoxyl pectin (LMP) dietary fiber in preventing T1D development. Female NOD mice were weaned onto control or 5% (wt/wt) LMP supplemented diets for up to 40 weeks of age, overt diabetes incidence and blood glucose were monitored. Then broad-spectrum antibiotics (ABX) treatment per os for 7 days followed by gut microbiota transfer was performed to demonstrate gut microbiota-dependent effects. Next-generation sequencing was used for analyzing the composition of microbiota in caecum. Concentration of short chain fatty acids were determined by GC-MS. The barrier reinforcing tight junction proteins zonula occludens-2 (ZO-2), claudin-1 and NOD like receptor protein 3 (NLRP3) inflammasome activation were determined by Western blot. The proportion of CD25

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Gastrointestinal MicrobiomeAnimalsCecumFemaleHumansMiceMice, Inbred NODPancreasPectinsT-Lymphocytes, RegulatoryPectinsautoimmune diabetesgut microbiotaimmunomodulationintestinal homeostasislow-methoxyl pectin

Identifiers

PMID31417546
PMCPMC6682655
OpenAlexW2962169910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.