Evidence map›Paper›PMID 31417517›Full record

ArticleFrontiers in microbiology2019

Differential Susceptibility of

Arthur H Totten, Cameron L Crawford, Alex G Dalecki, Li Xiao, Frank Wolschendorf, Thomas P Atkinson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Antimicrobial Activity of N,N-Diethyldithiocarbamate againstInternational journal of molecular sciences · 2023
    Article
  4. Biofilm · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Demonstration ofMicrobiology spectrum · 2021
    Article
  9. Frontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Arthur H TottenDepartment of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL, United States.
Cameron L CrawfordDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Alex G DaleckiDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Li XiaoDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Frank WolschendorfDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States.
Thomas P AtkinsonDepartment of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

HTS for copper-activated inhibitors against MRSAR01AI121364 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KUTSCH, OLAF · 2016 to 2018
$2.2M
NIAID NIH HHS R01 AI121364
6 · The paper itself

Abstract

rationaleMycoplasmas represent important etiologic agents of many human diseases. Due to increasing antimicrobial resistance and slow rate of novel discovery, unconventional methods of drug discovery are necessary. Copper ions are utilized in host microbial killing, and bacteria must regulate intracellular Cu concentrations to avoid toxicity. We hypothesized that human mollicutes may have susceptibility to Cu-induced toxicity, and compounds that augment copper-dependent killing.

methods

results

conclusionMICs for CuSO

Indexed as

copperdisulfiramdrug discoveryGTSMmollicutesMycoplasmaneocuproineUreaplasma

Identifiers

PMID31417517
PMCPMC6682632
OpenAlexW2958671640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.