Evidence map›Paper›PMID 31417424›Full record

ArticleFrontiers in physiology2019

TOR as a Regulatory Target in

Camila Waltero, Leonardo Araujo de Abreu, Thayná Alonso, Rodrigo Nunes-da-Fonseca, Itabajara da Silva Vaz, Carlos Logullo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Glucose metabolomic profile during embryogenesis in the tick Rhipicephalus microplus.Metabolomics : Official journal of the Metabolomic Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Camila WalteroLaboratório Integrado de Bioquímica Hatisaburo Masuda and Laboratório Integrado de Ciências Morfofuncionais, Instituto de Biodiversidade e Sustentabilidade NUPEM, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
Leonardo Araujo de AbreuLaboratório Integrado de Bioquímica Hatisaburo Masuda and Laboratório Integrado de Ciências Morfofuncionais, Instituto de Biodiversidade e Sustentabilidade NUPEM, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
Thayná AlonsoLaboratório Integrado de Bioquímica Hatisaburo Masuda and Laboratório Integrado de Ciências Morfofuncionais, Instituto de Biodiversidade e Sustentabilidade NUPEM, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
Rodrigo Nunes-da-FonsecaLaboratório Integrado de Bioquímica Hatisaburo Masuda and Laboratório Integrado de Ciências Morfofuncionais, Instituto de Biodiversidade e Sustentabilidade NUPEM, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
Itabajara da Silva VazInstituto Nacional de Ciência e Tecnologia em Entomologia Molecular (INCT-EM), Rio de Janeiro, Brazil.
Carlos LogulloLaboratório Integrado de Bioquímica Hatisaburo Masuda and Laboratório Integrado de Ciências Morfofuncionais, Instituto de Biodiversidade e Sustentabilidade NUPEM, Universidade Federal do Rio de Janeiro, Macaé, Brazil.
Universidade Federal do Rio de Janeiro · BRInstituto Nacional de Ciência e Tecnologia em Entomologia Molecular · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Embryogenesis is a metabolically intensive process carried out under tightly controlled conditions. The insulin signaling pathway regulates glucose homeostasis and is essential for reproduction in metazoan model species. Three key targets are part of this signaling pathway: protein kinase B (PKB, or AKT), glycogen synthase kinase 3 (GSK-3), and target of rapamycin (TOR). While the role of AKT and GSK-3 has been investigated during tick embryonic development, the role of TOR remains unknown. In this study, TOR and two other downstream effectors, namely S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), were investigated in

Indexed as

BME26embryogenesisRhipicephalus microplustarget of rapamycintick embryonic cells

Identifiers

PMID31417424
PMCPMC6684781
OpenAlexW2960302598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.