Evidence map›Paper›PMID 31417410›Full record

ArticleFrontiers in physiology2019

Mapping the Tooth Enamel Proteome and Amelogenin Phosphorylation Onto Mineralizing Porcine Tooth Crowns.

Daniel R Green, Fabian Schulte, Kyu-Ha Lee, Megan K Pugach, Markus Hardt, Felicitas B Bidlack

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Reduced Dietary Protein Induces Changes in the Dental Proteome.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2026
    Article
  4. JBMR plus · 2026
    Article
  5. Article
  6. Article
  7. Posteruptive Loss of Proteins in Porcine Enamel.Journal of dental research · 2025
    Article
  8. Review
  9. Proteomic profiling of human dental enamel affected by molar incisor hypomineralisation of different clinical severity grades: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024
    Article
  10. Article
  11. Article
  12. Label-free quantitative proteomics reveals molecular correlates of altered biomechanical properties in molar incisor hypomineralization (MIH): an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
    Article
  13. Article
  14. Advanced materials for enamel remineralization.Frontiers in bioengineering and biotechnology · 2022
    Review
  15. Sp6/Epiprofin is a master regulator in the developing tooth.Biochemical and biophysical research communications · 2021
    Article
  16. Grand Challenges in Comparative Tooth Biology.Integrative and comparative biology · 2020
    Article
  17. Tooth Enamel and its Dynamic Protein Matrix.International journal of molecular sciences · 2020
    Review
  18. Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?International journal of molecular sciences · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daniel R GreenThe Forsyth Institute, Cambridge, MA, United States.
Fabian SchulteThe Forsyth Institute, Cambridge, MA, United States.
Kyu-Ha LeeThe Forsyth Institute, Cambridge, MA, United States.
Megan K PugachThe Forsyth Institute, Cambridge, MA, United States.
Markus HardtThe Forsyth Institute, Cambridge, MA, United States.
Felicitas B BidlackThe Forsyth Institute, Cambridge, MA, United States.
Harvard University · US

Funding

Forsyth Training in Oral Health ResearchT90DE026110 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI THOMAS Elliott VAN DYKE · 2017 to 2026
$3.0M
Enamel matrix 3D organization and maturation stage ion flowR01DE025865 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BIDLACK, FELICITAS B · 2016 to 2020
$2.4M
Saliva-mediated Mechanisms of Post-Eruptive Enamel MineralizationR21DE026874 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BIDLACK, FELICITAS B · 2018 to 2019
$547k
NIDCR NIH HHS R01 DE025865NIDCR NIH HHS R21 DE026874NIDCR NIH HHS T90 DE026110
6 · The paper itself

Abstract

Tooth enamel forms in an ephemeral protein matrix where changes in protein abundance, composition and posttranslational modifications are critical to achieve healthy enamel properties. Amelogenin (AMELX) with its splice variants is the most abundant enamel matrix protein, with only one known phosphorylation site at serine 16 shown

Indexed as

amelogeninenamel mineralizationenamel proteomephosphorylationposttranslational modificationtooth enamel

Identifiers

PMID31417410
PMCPMC6682599
OpenAlexW2962516775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.