Evidence map›Paper›PMID 31417352›Full record

ArticleFrontiers in neuroscience2019

Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson's Disease.

Melissa Crabbé, Anke Van der Perren, Ilse Bollaerts, Savannah Kounelis, Veerle Baekelandt, Guy Bormans, Cindy Casteels, Lieve Moons, Koen Van Laere

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  11. Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star?International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Towards PET imaging of the dynamic phenotypes of microglia.Clinical and experimental immunology · 2021
    Review
  17. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  18. Article
  19. Review
  20. Inflaming the Brain with Iron.Antioxidants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Melissa CrabbéNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
Anke Van der PerrenLaboratory for Neurobiology and Gene therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Ilse BollaertsLaboratory of Neuronal Circuit Development and Regeneration, Department of Biology, KU Leuven, Leuven, Belgium.
Savannah KounelisNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
Veerle BaekelandtLaboratory for Neurobiology and Gene therapy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
Guy BormansMolecular Small Animal Imaging Center, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Cindy CasteelsNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
Lieve MoonsLaboratory of Neuronal Circuit Development and Regeneration, Department of Biology, KU Leuven, Leuven, Belgium.
Koen Van LaereNuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
KU Leuven · BEVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purinergic P2X7 receptor is a key mediator in (neuro)inflammation, a process that is associated with neurodegeneration and excitotoxicity in Parkinson's disease (PD). Recently, P2X7 imaging has become possible with [

Indexed as

6-OHDAP2X7Parkinson’s diseasetranslocator proteinα-synuclein

Identifiers

PMID31417352
PMCPMC6684733
OpenAlexW2961930094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.