Evidence map›Paper›PMID 31417339›Full record

ArticleFrontiers in neuroscience2019

Electroencephalography and Functional Magnetic Resonance Imaging-Guided Simultaneous Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in a Patient With Minimally Conscious State.

Yicong Lin, Tiaotiao Liu, Qian Huang, Yingying Su, Weibi Chen, Daiquan Gao, Xin Tian, Taicheng Huang, Zonglei Zhen, Tao Han and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Observational
  7. Review
  8. Advances in Stroke Neurorehabilitation.Journal of clinical medicine · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yicong LinDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Tiaotiao LiuSchool of Biomedical Engineering, Tianjin Medical University, Tianjin, China.
Qian HuangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yingying SuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Weibi ChenDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Daiquan GaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xin TianSchool of Biomedical Engineering, Tianjin Medical University, Tianjin, China.
Taicheng HuangState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Zonglei ZhenState Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.
Tao HanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hong YeDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuping WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNChinese Institute for Brain Research · CNTianjin Medical University · CNBeijing Normal University · CN

Funding

Regulation of hepatic stellate cells in development and alcoholic liver injuryR00AA020514 · NIAAA · CINCINNATI CHILDRENS HOSP MED CTR · PI YIN, CHUNYUE · 2014 to 2016
$722k
Regulation of hepatic stellate cells in development and alcoholic liver injuryK99AA020514 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YIN, CHUNYUE · 2011 to 2012
$179k
NIAAA NIH HHS K99 AA020514NIAAA NIH HHS R00 AA020514
6 · The paper itself

Abstract

objectiveA minimally conscious state (MCS) is characterized by discernible behavioral evidence of consciousness that cannot be reproduced consistently. This condition is highly challenging to treat. Recent studies have demonstrated the potential therapeutic effect of non-invasive brain stimulation in patients with MCS. In one patient in an MCS, we delivered simultaneous transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) based on an individual brain network analysis and evaluated the therapeutic effect.

methodsThe directional transfer function (DTF) was calculated based on electroencephalograph (EEG) analysis. Global brain connectivity was calculated based on functional magnetic resonance imaging (fMRI) analysis. By referring to the EEG and fMRI results, we identified inferior parietal lobes (IPLs) as targets. In the 2-week treatment period, 14 sessions were applied to the identified bilateral parietal regions. Simultaneous 1.5-mA anodal tDCS and 5-Hz rTMS were delivered for 20 min per hemisphere in each session. Clinical evaluation scores were recorded weekly throughout the treatment. A second patient given the routine treatment was evaluated as a control.

resultsThe clinical scores of patient 1 with MCS improved after 2 weeks of stimulation treatment, and the effect lasted for up to 1 month. EEG analysis showed a significant increase (

conclusionThe application of EEG and fMRI to characterize the functional connectivity features of the network in an MCS patient provided a reasonable and accurate stimulation target and verified the changes in functional connectivity resulting from stimulation.

Indexed as

functional magnetic resonance imagingminimally conscious staterepetitive transcranial magnetic stimulationsimultaneous stimulationtranscranial direct current stimulation

Identifiers

PMID31417339
PMCPMC6685103
OpenAlexW2955198983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.