ArticleScientific reports2019
Non-professional phagocytosis: a general feature of normal tissue cells.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Macrophage-mediated nutrient recycling: evolutionary insights into the metabolic role of professional phagocytes.Frontiers in immunology · 2026Review
- Single-cell transcriptomics reveals stepwise transformation of epithelial cells into Non-Professional Phagocytes.PLoS genetics · 2025Article
- Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair.Seminars in respiratory and critical care medicine · 2025Review
- Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Internalization ofMicroorganisms · 2025Article
- Relevance of Lipoprotein Composition in Endothelial Dysfunction and the Development of Hypertension.International journal of molecular sciences · 2025Review
- Sacrificing cells of the cyst: non-apoptotic cell death in germline cysts via acidification.Frontiers in cell death · 2025Article
- Efferocytosis and Bone Dynamics.Current osteoporosis reports · 2024Review
- Advancing stroke recovery: unlocking the potential of cellular dynamics in stroke recovery.Cell death discovery · 2024Review
- Widespread sex dimorphism across single-cell transcriptomes of adult African turquoise killifish tissues.Cell reports · 2023Article
- Non-Professional Phagocytosis Increases in Melanoma Cells and Tissues with Increasing E-Cadherin Expression.Current oncology (Toronto, Ont.) · 2023Article
- Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling.Cell death & disease · 2023Article
- Surface physical cues mediate the uptake of foreign particles by cancer cells.APL bioengineering · 2023Article
- Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues.APL bioengineering · 2023Article
- Unrevealing the Mystery of Latent Leishmaniasis: What Cells Can HostPathogens (Basel, Switzerland) · 2023Review
- Article
- Effect of Citrate- and Gold-Stabilized Superparamagnetic Iron Oxide Nanoparticles on Head and Neck Tumor Cell Lines during Combination Therapy with Ionizing Radiation.Bioengineering (Basel, Switzerland) · 2022Article
- Dynamics of phagocytosis mediated by phosphatidylserine.Biochemical Society transactions · 2022Review
- Receptor for advanced glycation end-products (RAGE) mediates phagocytosis in nonprofessional phagocytes.Communications biology · 2022Article
- Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction.Nature cardiovascular research · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-professional phagocytosis by cancer cells has been described for decades. Recently, non-professional phagocytosis by normal tissue cells has been reported, which prompted us to take a closer look at this phenomenon. Non-professional phagocytosis was studied by staining cultured cells with live-cell staining dyes or by staining paraffin-embedded tissues by immunohistochemistry. Here, we report that each of 21 normal tissue cell lines from seven different organs was capable of phagocytosis, including ex vivo cell cultures examined before the 3rd passage as well as the primary and virus-transformed cell lines. We extended our analysis to an in vivo setting, and we found the occurrence of non-professional phagocytosis in healthy skin biopsies immediately after resection. Using dystrophin immunohistochemistry for membrane staining, human post-infarction myocardial tissue was assessed. We found prominent signs of non-professional phagocytosis at the transition zone of healthy and infarcted myocardia. Taken together, our findings suggest that non-professional phagocytosis is a general feature of normal tissue cells.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.