ArticleThe Indian journal of medical research2019
Different gene expression profiles in subcutaneous & visceral adipose tissues from Mexican patients with obesity.
Article in The Indian journal of medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Pooled it
- Adipose tissue transcriptome before and after surgery: effects on genes driving lipid metabolism, inflammation, and RNA processing.International journal of obesity (2005) · 2026Article
- CD248 expression in human adipose tissue is upregulated in obesity and following glucocorticoid exposure: a mediator of insulin resistance and adipose dysfunction?Molecular medicine (Cambridge, Mass.) · 2026Article
- Understanding adipocyte heterogeneity across species, depot, and disease.Biochemical Society transactions · 2026Review
- Tissue-Specific Multi-Omics Integration Demonstrates Molecular Signatures Connecting Obesity to Immune Vulnerability.Metabolites · 2026Article
- The Role of microRNA-22 in Metabolism.International journal of molecular sciences · 2025Review
- In silico and functional analysis identifies key gene networks and novel gene candidates in obesity-linked human visceral fat.Obesity (Silver Spring, Md.) · 2024Article
- Article
- Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer: AKT3 and MAPK1 Cross Point in Obesity.Journal of obesity · 2024Article
- The association of dietary insulin load and dietary insulin index with body composition among professional soccer players and referees.BMC sports science, medicine & rehabilitation · 2023Article
- The Role of Olfactomedin 2 in the Adipose Tissue-Liver Axis and Its Implication in Obesity-Associated Nonalcoholic Fatty Liver Disease.International journal of molecular sciences · 2023Article
- Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa.Frontiers in genetics · 2023Article
- Fat-to-heart crosstalk in health and disease.Frontiers in genetics · 2023Review
- Adipocyte differentiation between obese and lean conditions depends on changes in miRNA expression.Scientific reports · 2022Article
- A potent HNF4α agonist reveals that HNF4α controls genes important in inflammatory bowel disease and Paneth cells.PloS one · 2022Article
- Effect of Differences in the Microbiome ofCells · 2021Article
- Breastfeeding history and the risk of overweight and obesity in middle-aged women.BMC women's health · 2021Article
- Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry.Antioxidants (Basel, Switzerland) · 2021Review
- 20-HETE interferes with insulin signaling and contributes to obesity-driven insulin resistance.Prostaglandins & other lipid mediators · 2021Article
- Heterogeneous miRNA-mRNA Regulatory Networks of Visceral and Subcutaneous Adipose Tissue in the Relationship Between Obesity and Renal Clear Cell Carcinoma.Frontiers in endocrinology · 2021Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & objectives: Obesity is a health problem that requires substantial efforts to understand the physiopathology of its various types and to determine therapeutic strategies for its treatment. The objective of this study was to characterize differences in the global gene expression profiles of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) between control patients (normal weight) and patients with obesity (IMC≥30) using microarrays. Methods: Employing RNA isolated from SAT and VAT samples obtained from eight control and eight class I, II and III patients with obesity, the gene expression profiles were compared between SAT and VAT using microarrays and the findings were validated via real-time quantitative polymerase chain reaction. Results: A total of 327 and 488 genes were found to be differentially expressed in SAT and VAT, respectively (P≤0.05). Upregulation of PPAP2C, CYP4A11 and CYP17A1 genes was seen in the VAT of obese individuals. Interpretation & conclusions: SAT and VAT exhibited significant differences in terms of the expression of specific genes. These genes might be related to obesity. These findings may be used to improve the clinical diagnosis of obesity and could be a tool leading to the proposal of new therapeutic strategies for the treatment of obesity.
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Registered trials
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