ArticleScience (New York, N.Y.)2019
Genetic behavioral screen identifies an orphan anti-opioid system.
Open access · bronzeAbstract readVideo-Audio Media
In one paragraph
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 68 citations in OpenAlex.
- Article
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- Emerging Insights into the Distinct Pharmacological Mechanisms of Buprenorphine.Journal of chemical information and modeling · 2026Article
- Olfactory-gustatory cross-modal integration: mechanisms of aroma-induced sweetness enhancement, sensory evaluation methodologies, neuroimaging evidence and advances in influencing factors.Journal of advanced research · 2026Review
- Targeting Mu Opioid Receptor Neurons of the Habenula to Limit Naloxone Aversion.Biological psychiatry · 2026Article
- Review: "The Disappointment Dilemma: Short- and Long-Term Learning From Negative Outcomes".The European journal of neuroscience · 2026Review
- G protein regulatory network shapes magnitude and kinetics of behavioral responses in an engineered opioid receptor model.The Journal of biological chemistry · 2026Article
- Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives.Molecular pharmacology · 2026Review
- GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Advances in drug addiction research usingFrontiers in cell and developmental biology · 2026Review
- A brain-to-small intestine circuit mediates morphine-induced constipation in male mice.Nature communications · 2025Article
- Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139.Nature communications · 2025Article
- Orphan Receptor GPRC5B Controls Adult Hippocampal Neurogenesis and Affects Retinoic Acid-Mediated Behaviors.Molecular neurobiology · 2025Article
- Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor.Nature communications · 2025Article
- Mu-opioid receptor activation potentiates excitatory transmission at the habenulo-peduncular synapse.Cell reports · 2025Article
- GPR139, an Ancient Receptor and an Emerging Target for Neuropsychiatric and Behavioral Disorders.Molecular neurobiology · 2025Review
- Research Progress of GPR137 in Malignant Tumors: A Review.OncoTargets and therapy · 2025Review
- Orphan GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches.Current issues in molecular biology · 2024Review
- Emerging modes of regulation of neuromodulatory G protein-coupled receptors.Trends in neurosciences · 2024Review
- Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder.British journal of pharmacology · 2024Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Dandan WangDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0002-5626-8968
Hannah M StovekenDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Stefano ZuccaDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0002-8781-3295
Maria DaoDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Cesare OrlandiDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0002-4992-9350
Chenghui SongDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0003-3289-809X
Ikuo MasuhoDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Caitlin JohnstonDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0003-1383-6731
Karla J OppermanDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.
Andrew C GilesDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0002-0875-0696
Matthew S GillDepartment of Molecular Medicine, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0003-0818-8792
Erik A LundquistDepartment of Molecular Biosciences, The University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0001-6819-4815
Brock GrillDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA. kirill@scripps.edu bgrill@scripps.edu.ORCID 0000-0002-0379-3267
Kirill A MartemyanovDepartment of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA. kirill@scripps.edu bgrill@scripps.edu.ORCID 0000-0002-9925-7599
Scripps Research Institute · USUniversity of Kansas · US
Funding
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HARTLEY, MEREDITH D · 2012 to 2021
$22.1MMechanisms of synapse formation and axon termination in C. elegansR01NS072129 · NINDS · UNIVERSITY OF MINNESOTA · PI GRILL, BROCK · 2011 to 2024
$8.0MUCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9MRegulation of Striatal Signaling by RGS ProteinsR01DA036596 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov · 2014 to 2026
$6.5MMolecular Basis of RGS Protein Function in the StriatumK02DA026405 · NIDA · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2009 to 2019
$1.2MA transgenic model of opioid tolerance and drug discoveryR21DA040406 · NIDA · SCRIPPS FLORIDA · PI GRILL, BROCK, MARTEMYANOV, KIRILL A. · 2015 to 2016
$478kMetabotropic glutamate regulation of synaptic rewiring in opioid addictionF32DA048579 · NIDA · SCRIPPS FLORIDA · PI ZUCCA, STEFANO · 2019 to 2021
$219kInvestigating New Roles for Orphan GPCRs in Opioid ActionsF32DA047771 · NIDA · SCRIPPS FLORIDA · PI STOVEKEN, HANNAH MARIE · 2019 to 2021
$135kNCRR NIH HHS U42 RR024244NIDA NIH HHS F32 DA047771NIDA NIH HHS F32 DA048579NIDA NIH HHS K02 DA026405NIDA NIH HHS R01 DA036596NIDA NIH HHS R21 DA040406NIGMS NIH HHS P20 GM103638NINDS NIH HHS R01 NS072129
Abstract
Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management, but their addictive properties can lead to severe abuse. We developed a whole-animal behavioral platform for unbiased discovery of genes influencing opioid responsiveness. Using forward genetics in
Indexed as
Behavior, AnimalAnalgesiaAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansChromosome MappingCRISPR-Cas SystemsFemaleHEK293 CellsHumansMaleMiceMice, KnockoutMorphineNerve Tissue ProteinsNeuronsGPR139 protein, humanGpr139 protein, mouseMorphineNerve Tissue ProteinsOrphan Nuclear ReceptorsReceptors, G-Protein-CoupledReceptors, Opioid, mu
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.