Evidence map›Paper›PMID 31416928›Full record

ArticleDisease models & mechanisms2019

Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis.

Stephanie Young, Namit Sharma, Jae Hoon Lee, Violeta Chitu, Volker Neumeister, Elisabeth Sohr, E Richard Stanley, Christian M Hedrich, Andrew W B Craig

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Stephanie YoungDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Namit SharmaDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Jae Hoon LeeDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Violeta ChituDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Volker NeumeisterDepartments of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden 01307, Germany.
Elisabeth SohrPediatric Rheumatology and Immunology, Children's Hospital Dresden, Technical University Dresden, Dresden 01307, Germany.
E Richard StanleyDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Christian M HedrichPediatric Rheumatology and Immunology, Children's Hospital Dresden, Technical University Dresden, Dresden 01307, Germany.ORCID 0000-0002-1295-6179
Andrew W B CraigDepartment of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada andrew.craig@queensu.ca.ORCID 0000-0002-2039-2393
Queen's University · CAAlbert Einstein College of Medicine · USTechnische Universität Dresden · DEUniversity Hospital Carl Gustav Carus · DEUniversity of Liverpool · GB

Funding

HEMOPOIETIC STEM CELL DIFFERENTIATION TO MACROPHAGESR01CA032551 · NCI · YESHIVA UNIVERSITY · PI STANLEY, E. RICHARD · 1985 to 2013
$5.4M
CIHR MOP 82882NCI NIH HHS R01 CA032551
6 · The paper itself

Abstract

Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease, and patients with active or recurrent bone inflammation at multiple sites are diagnosed with chronic recurrent multifocal osteomyelitis (CRMO). The Chronic multifocal osteomyelitis (CMO) mouse model develops IL-1β-driven sterile bone lesions reminiscent of severe CRMO. The goal of this study was to evaluate the potential involvement of mast cells in CMO/CRMO. Here, we show that mast cells accumulate in inflamed tissues from CMO mice and that mast cell protease Mcpt1 can be detected in the peripheral blood. A transgenic model of connective tissue mast cell depletion (

Indexed as

AnimalsBone and BonesChronic DiseaseConnective TissueHumansInflammationInterleukin-1betaLymph NodesMast CellsMice, Inbred BALB CModels, BiologicalOsteomyelitisInterleukin-1betaAutoinflammationBone diseaseChronic recurrent multifocal osteomyelitisCNOCytokinesInterleukin-1β

Identifiers

PMID31416928
PMCPMC6737947
OpenAlexW2964687713

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.