Trial reportJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2019
Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke.
Trial report in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Characterization of a fiber-coupled SPAD camera system for deep-tissue blood-flow measurement using diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- A Device-on-Chip Solution for Real-Time Diffuse Correlation Spectroscopy Using FPGA.Biosensors · 2024Article
- Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements.PloS one · 2024Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064 nm using superconducting nanowire single photon detectors in a neuro intensive care unit.Biomedical optics express · 2022Article
- Lossless Compressed Sensing of Photon Counts for Fast Diffuse Correlation Spectroscopy.IEEE access : practical innovations, open solutions · 2022Article
- Accuracy of diffuse correlation spectroscopy measurements of cerebral blood flow when using a three-layer analytical model.Biomedical optics express · 2021Article
- Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report.Brain sciences · 2021Article
- Hematocrit significantly confounds diffuse correlation spectroscopy measurements of blood flow.Biomedical optics express · 2020Article
- Dynamic autoregulation of cerebral blood flow measured non-invasively with fast diffuse correlation spectroscopy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
goalsWe quantified cerebral blood flow response to a 500 cc bolus of 0.9%% normal saline (NS) within 96 hours of acute ischemic stroke (AIS) using diffuse correlation spectroscopy (DCS). MATERIALS AND
methodsSubjects with AIS in the anterior, middle, or posterior cerebral artery territory were enrolled within 96 hours of symptom onset. DCS measured relative cerebral blood flow (rCBF) in the bilateral frontal lobes for 15 minutes at rest (baseline), during a 30-minute infusion of 500 cc NS (bolus), and for 15 minutes after completion (post-bolus). Mean rCBF for each time period was calculated for individual subjects and median rCBF for the population was compared between time periods. Linear regression was used to evaluate for associations between rCBF and clinical features.
resultsAmong 57 subjects, median rCBF (IQR) increased relative to baseline in the ipsilesional hemisphere by 17% (-2.0%, 43.1%), P< 0.001, and in the contralesional hemisphere by 13.3% (-4.3%, 36.0%), P < .004. No significant associations were found between ipsilesional changes in rCBF and age, race, infarct size, infarct location, presence of large vessel stenosis, NIH stroke scale, or symptom duration.
conclusionA 500 cc bolus of .9% NS produced a measurable increase in rCBF in both the affected and nonaffected hemispheres. Clinical features did not predict rCBF response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.