SynthesisMutation research. Reviews in mutation research
Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.
Synthesis in Mutation research. Reviews in mutation research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Is Micronucleus Assay a Suitable Biomarker for Evaluating the Cancer Risk in Professionals Exposed to Antineoplastic Drugs? A Systematic Review.Journal of applied toxicology : JAT · 2026Pooled it
- Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data.International journal of environmental research and public health · 2022Pooled it
- Administering Antineoplastic Parenteral Cancer Therapy in the Patient's Home: Perspectives of Oncology Nurses-A Descriptive Qualitative Study.Nursing open · 2026Article
- Occupational Reproductive Health Risks Among Women Healthcare Workers: A Narrative Review for Clinical Surveillance, Preconception Counseling, and Prevention.Journal of clinical medicine · 2026Review
- Reducing Antineoplastic Drug Surface Contamination in an Outpatient Oncology Clinic: A Quality Improvement Project.Clinical journal of oncology nursing · 2025Article
- Economic evaluation of a robotic chemotherapy compounding system and its service expansion to network hospital in Thailand.BMC health services research · 2025Article
- 5-Bromouracil-gracillin (5BrU-G) complex: an APOBEC3-activated therapeutic strategy exploiting cancer-specific enzymatic activity for selective cytotoxicity.Medical oncology (Northwood, London, England) · 2025Article
- Do the azo food colorings carmoisine and ponceau 4R have a genotoxic potential?Toxicology research · 2025Article
- Assessing Etoposide and Cyclophosphamide Contamination and Current Cleaning Practices in Patient Bathrooms.Clinical journal of oncology nursing · 2025Article
- Metabolomic analysis of the impact of red ginseng on equine physiology.Frontiers in veterinary science · 2024Article
- Investigation of genotoxic effect of octyl gallate used as an antioxidant food additive in in vitro test systems.Mutagenesis · 2023Article
- Safe handling of hazardous drugs.Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners · 2023Article
- Review
- A LC-MS/MS based methodology for the environmental monitoring of healthcare settings contaminated with antineoplastic agents.Journal of public health research · 2023Article
- Real-world study of the leakage of two types of infusion bags in multicenter pharmacy intravenous admixture service (PIVAS).Frontiers in pharmacology · 2023Article
- A Critical Scoping Review of Pesticide Exposure Biomonitoring Studies in Overhead Cultures.Toxics · 2022Article
- Evaluation of three barrier-type closed system transfer devices using the 2015 NIOSH vapor containment performance draft protocol.Drugs & therapy perspectives : for rational drug selection and use · 2022Article
- Chromosome Aberrations in Lymphocytes of Patients Undergoing Radon Spa Therapy: An Explorative mFISH Study.International journal of environmental research and public health · 2021Article
- Cytostatics in Indoor Environment: An Update of Analytical Methods.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Many antineoplastic drugs used to treat cancer, particularly alkylating agents and topoisomerase inhibitors, are known to induce genetic damage in patients. Elevated levels of chromosomal aberrations, micronuclei, and DNA damage have been documented in cancer patients. Elevations in these same biomarkers of genetic damage have been reported in numerous studies of healthcare workers, such as nurses and pharmacists, who routinely handle these drugs, but results vary across studies. To obtain an overall assessment of the exposure effect, we performed a meta-analysis on data obtained from peer-reviewed publications reporting chromosomal aberration levels in healthcare workers exposed to antineoplastic drugs. A literature search identified 39 studies reporting on occupational exposure to antineoplastic drugs and measurement of chromosomal aberrations in healthcare workers. After applying strict inclusion criteria for data quality and presentation, data from 17 studies included in 16 publications underwent meta-analysis using Hedges' bias-corrected g and a random-effects model. Results showed the level of chromosomal aberrations in healthcare workers exposed to antineoplastic drugs was significantly higher than in controls. The standardized mean differences (difference of means divided by within sd) from all studies were pooled, yielding a value 1.006 (unitless) with p<0.001. Thus, in addition to the documented genotoxic effects of antineoplastic drugs in cancer patients, this meta-analysis confirmed a significant association between occupational exposure to antineoplastics during the course of a normal work day and increases in chromosomal aberrations in healthcare workers. Based on the studies reviewed, we were unable to accurately assess whether appropriate use of protective measures might reduce the incidence of genetic damage in healthcare workers. However, given the potential for increased cancer risk linked to increases in chromosomal aberrations, the results of this study support the need to limit occupational exposure of healthcare workers to antineoplastic drugs as much as possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.