ReviewRadiation oncology (London, England)2019
The role of squamous cell carcinoma antigen (SCC Ag) in outcome prediction after concurrent chemoradiotherapy and treatment decisions for patients with cervical cancer.
Review in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 93 citations in OpenAlex.
- Article
- Integrated bioinformatics, machine learning, and experimental validation identify a four-gene diagnostic signature for cervical cancer associated with PI3K/AKT signaling.Scientific reports · 2026Article
- Overexpression of cat eye syndrome chromosome region, candidate 2 in esophageal squamous carcinoma cell promotes tumor aggressiveness by facilitating NF-κB signaling and inhibition of p53-associated apoptosis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Observational
- Advances in Cervical Cancer Diagnostics Based on Immunosensors: Innovative Approaches and Tumor Biomarkers.Current topics in medicinal chemistry · 2026Review
- A warning to young women: a case of giant ovarian mature cystic teratoma with squamous cell carcinoma transformation in a 22-year-old female and analysis of its molecular features.American journal of cancer research · 2026Article
- Integrating Biomarkers into Cervical Cancer Screening-Advances in Diagnosis and Risk Prediction: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Serum Squamous Cell Carcinoma Markers: A Case-Control Study for Cervical Cancer.Clinical medicine & research · 2025Article
- Observational
- Multimodal deep learning model for prognostic prediction in cervical cancer receiving definitive radiotherapy: a multi-center study.NPJ digital medicine · 2025Article
- Serum soluble Tim‑3 is elevated in patients with cervical cancer and is higher in advanced clinical stages.Biomedical reports · 2025Article
- Predictors of distant metastasis or local recurrent after radiotherapy in patients with cervical cancer.BMC cancer · 2025Article
- Article
- Anti-Estrogen Therapy Achieves Complete Remission and Stability in Recurrent Cervical Cancer: A Case Study.The American journal of case reports · 2025Article
- Analysis of the efficacy and safety of camrelizumab combined with chemotherapy for cervical cancer treatment.Frontiers in oncology · 2025Article
- Development, validation, and visualization of a novel nomogram for predicting clinical outcomes of radiotherapy combined with chemotherapy in locally advanced cervical cancer.Frontiers in oncology · 2025Article
- Efficacy and prognosis of concurrent chemoradiotherapy in the management of recurrent cervical cancer: a retrospective study.American journal of translational research · 2025Article
- Rare metastasis of the urinary bladder from esophageal squamous cell carcinoma: a case report.Frontiers in oncology · 2025Article
- Article
- Primary lung adenocarcinoma harboring upper mediastinal lymphatic skip metastasis of cervical squamous cell carcinoma: A case report and literature review.Oncology letters · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated with extensive tumors and poor survival for patients with cervical cancer treated with definitive CCRT. SCC Ag levels can be used to help physicians make decisions regarding surgery, avoiding the complications of double treatment modalities. Elevated SCC Ag is associated with radiotherapy resistance, and the rate of SCC Ag reduction during CCRT can predict tumor response after treatment. Moreover, the failure of SCC Ag levels to normalize posttreatment can predict tumor relapse, with a specificity higher than 70%, and adjuvant therapies should be considered for these patients. SCC Ag also plays an important role in the early detection of tumor relapse in patients with cervical cancer during follow-up after CCRT, with high sensitivity and good cost-effectiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.