Evidence map›Paper›PMID 31416220›Full record

ArticleInternational journal of molecular sciences2019

Bioactivity and Bactericidal Mechanism of Histidine-Rich β-Hairpin Peptide Against Gram-Negative Bacteria.

Na Dong, Chensi Wang, Tingting Zhang, Lei Zhang, Chenyu Xue, Xinjun Feng, Chongpeng Bi, Anshan Shan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
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  7. Protegrin-1 and Analogues AgainstPharmaceuticals (Basel, Switzerland) · 2025
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  10. Antibacterial Activity and Cytotoxicity of the Novel Bacteriocin Pkmh.International journal of molecular sciences · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Engineered Cyclotides with Potent Broad in Vitro and in Vivo Antimicrobial Activity.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Na DongLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Chensi WangLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Tingting ZhangLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Lei ZhangLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Chenyu XueLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Xinjun FengLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Chongpeng BiLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China.
Anshan ShanLaboratory of Molecular Nutrition and Immunity. The Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China. asshan@neau.edu.cn.
Northeast Agricultural University · CN

Funding

the Academic Backbone Project of Northeast Agricultural University 16XG14the China Postdoctoral Science Foundation 2015M571385the National Natural Science Foundation of China 31501914, 31472104 and 31672434the Natural Science Foundation of Heilongjiang Province TD2019C001The Natural Science Foundation of Heilongjiang Province LH2019C023the Special Financial Grant from the China Postdoctoral Science Foundation 2016T90267
6 · The paper itself

Abstract

Antibacterial peptides (APMs) are a new type of antibacterial substance. The relationship between their structure and function remains indistinct; in particular, there is a lack of a definitive and fixed template for designing new antimicrobial peptides. Previous studies have shown that porcine Protegrin-1 (PG-1) exhibits considerable antimicrobial activity and cytotoxicity. In this study, to reduce cytotoxicity and increase cell selectivity, we designed histidine-rich peptides based on the sequence template RR(XY)

Indexed as

HistidineAmino Acid SequenceAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesCell Membrane PermeabilityDrug DesignGram-Negative BacteriaMiceMicrobial Sensitivity TestsModels, MolecularMolecular ConformationPeptidesProtein Conformation, beta-StrandRAW 264.7 CellsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesHistidinePeptidesprotegrin-1bactericidal mechanismbiological activityhistidineβ-hairpin antimicrobial peptides

Identifiers

PMID31416220
PMCPMC6718988
OpenAlexW2968682755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.